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1.D.288.  The Ziapin2-mediated Photostimulation of Excitation-Contraction Coupling (ZP-ECC) Family

A report reveals a role of stretch-activated channels in light-generated action potentials mediated by an intramembrane molecular photoswitch (Florindi et al. 2024). Ziapin2, a newly synthesized azobenzene compound, is an efficient tool for light-driven modulation of excitation-contraction coupling (ECC) in human-induced pluripotent stem cell-derived cardiomyocytes.  Ziapin2 can photomodulate cardiac ECC in mature AMVMs without affecting the main transporters and receptors located within the sarcolemma.  A connection was established between Ziapin2-induced membrane thickness modulation and light-generated action potentials (Florindi et al. 2024).

References associated with 1.D.288 family:

Florindi, C., V. Vurro, P. Moretti, C. Bertarelli, A. Zaza, G. Lanzani, and F. Lodola. (2024). Role of stretch-activated channels in light-generated action potentials mediated by an intramembrane molecular photoswitch. J Transl Med 22: 1068. 39605022