1.D.288. The Ziapin2-mediated Photostimulation of Excitation-Contraction Coupling (ZP-ECC) Family
A report reveals a role of stretch-activated channels in light-generated action potentials mediated by an intramembrane molecular photoswitch (Florindi et al. 2024). Ziapin2, a newly synthesized azobenzene compound, is an efficient tool for light-driven modulation of excitation-contraction coupling (ECC) in human-induced pluripotent stem cell-derived cardiomyocytes. Ziapin2 can photomodulate cardiac ECC in mature AMVMs without affecting the main transporters and receptors located within the sarcolemma. A connection was established between Ziapin2-induced membrane thickness modulation and light-generated action potentials (Florindi et al. 2024).