TCDB is operated by the Saier Lab Bioinformatics Group

1.D.293.  The Chloride Channel with Molecular Hourglass Shape and Anion-Pi-Interactions           

(HG-AP-CLC) Family

ClC is the main family of natural chloride channel proteins that transport Cl- across the cell membrane with high selectivity (Huang et al. 2024). The chloride transport and selectivity are determined by the hourglass-shaped pore and the filter located in the central and narrow region of the pore. Artificial unimolecular channels that mimics both the shape and function of the ClC selective pore could provide simple molecular models to probe the intriguing mechanism and structure-function relevance of ClCs. Huang et al. 2024 elaborated upon the concept of molecular hourglass plus anion-π interactions for this purpose. The concept was validated by experimental results of molecular hourglasses using shape-persistent 1,3-alternate tetraoxacalix[2]arene[2]triazine as the central macrocyclic skeleton to control the conductance and selectivity, and anion-π interactions as the driving force to facilitate the chloride dehydration and movement along the channel.

References associated with 1.D.293 family:

Huang, W.L., X.D. Wang, Y.F. Ao, Q.Q. Wang, and D.X. Wang. (2024). Mimicking the Shape and Function of the ClC Chloride Channel Selective Pore by Combining a Molecular Hourglass Shape with Anion-π Interactions. Chemistry 30: e202304222. 38270386