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1.D.298.  The Synthetic CFTR-like Preferentially Anionic Channel (SCPAC) Family 

CFTR possesses a positively charged ion conduction pathway within its transmembrane domain, which serves as the core module for promoting the movement of anions across cell membranes. Mao et al. 2024 developed novel artificial anion channels by rebuilding the positively charged ion permeation pathway of CFTR in artificial systems. These synthetic molecules can be efficiently inserted into lipid bilayers to form artificial ion channels, which exhibit a preference for anions during the transmembrane transport process. The positively charged amino acid residues located in the ion permeation pathway of these artificial channels can promote the transmembrane transport of anions through electrostatic interactions, which is consistent with the mechanism of anion transmembrane transport achieved by CFTR (Mao et al. 2024).

References associated with 1.D.298 family:

Mao, L., S. Hou, L. Shi, J. Guo, B. Zhu, Y. Sun, J. Chang, and P. Xin. (2024). Synthetic anion channels: achieving precise mimicry of the ion permeation pathway of CFTR in an artificial system. Chem Sci 16: 371-377. 39620072