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1.D.44 The Synthetic Ion Channel with Redox-active Ferrocene (ICRF) Family. 

The synthesis, cation binding and transmembrane conductive properties of a novel synthetic ion channel compound containing a redox-active ferrocene unit have been described by Tsikolia et al. 2009. Fluorescence spectroscopy was used to demonstrate that the channel supports multiple ion coordination and association constants for 1:1 and 1:2 (channel:cation) coordination for both Na+ and K+. Experiments using a black lipid membrane preparation revealed that this compound functioned effectively as an ion channel for both ions, and 23Na+ NMR spectroscopy  revealed a Na+ flux, at least 5 times higher than ion transport rates by monensin. Furthermore, oxidation of the redox-active centre (Fe2+ to Fe3+) effectively inhibited ion transport.

References associated with 1.D.44 family:

Tsikolia, M., A.C. Hall, C. Suarez, Z.O. Nylander, S.M. Wardlaw, M.E. Gibson, K.L. Valentine, L.N. Onyewadume, D.A. Ahove, M. Woodbury, M.M. Mongare, C.D. Hall, Z. Wang, B. Draghici, and A.R. Katritzky. (2009). Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayers. Org Biomol Chem 7: 3862-3870. 19707694