1.D.81. The Synthetic Tetrapeptide Amphiphile (TPA) Family
Basak et al. 2017 reported a minimalistic tetrapeptide amphiphile (MPA1), derived from alanine and aminopicolinic acid that forms cation selective pores in lipid bilayers. A dimeric structure appears to form the ion-transporting pore. The pore shows a preference for Na+ owing to the oligoether chain at the C-terminus. These tetrapeptide scaffolds have a long open lifetime. Such small peptides containing pyridine can potentially be utilized for pH modulated ion transport. The basic scaffold is shown below.
References associated with 1.D.81 family:
Basak, D., S. Sridhar, A.K. Bera, and N. Madhavan. (2017). A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium. Bioorg Med Chem Lett. [Epub: Ahead of Print] 28487073