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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
1.E.5.1.1	P35 holin of phage PRD1 (Rydman and Bamford 2003; Ziedaite et al. 2005). This holin is up to 98% identical to the holins of plasmid-dependent tectiviruses (Quinones-Olvera et al. 2024). Cell death can be dependent on holins LrgAB repressed by a novel ArsR family regulator CdsR (Zhang et al. 2024).	Viruses	Bamfordvirae, Preplasmiviricota	P35 protein of Bacteriophage PRD1 (Q3T4L9)
1.E.5.1.2	Phage holin	Bacteria	Pseudomonadota	Phage holin of of Providencia stuartii
1.E.5.1.3	Putative holin	Viruses	Heunggongvirae, Uroviricota	Putative holin of Xanthomonas phage vB_XSVEM_DIBBI
1.E.5.1.4	Putative holin (106 aas)	Bacteria	Pseudomonadota	Putative holin of Pantoea stewartii
1.E.5.1.5	Uncharacterized protein	Bacteria	Pseudomonadota	Uncharacterized protein of Methyloversatilis universalis
1.E.5.1.6	putative phage holin pg30	Viruses	Heunggongvirae, Uroviricota	gp30 of Burkholderia phage Bcep43
1.E.5.1.7	Uncharacterized protein of 112 aas and 3 TMSs	Bacteria		UP of Parcubacteria group bacterium
1.E.5.2.1	Phage-related protein (105 aas)	Bacteria	Campylobacterota	Phage-related protein of Nitratiruptor sp. strain SB155-2
1.E.5.2.2	Uncharacterized protein	Bacteria	Pseudomonadota	Uncharacterized protein of Vibrio mimicus
1.E.5.2.3	Putative holin	Viruses	Heunggongvirae, Uroviricota	Putative holin of proteobacterial phage
1.E.5.2.4	Uncharacterized protein	Bacteria	Pseudomonadota	Uncharacterized protein of Nitrosomonas eutropha
1.E.5.2.5	Putative holin of 134 aas and 3 TMSs.	Bacteria	Pseudomonadota	Holin of E. coli
1.E.5.2.6	Putative holin of 107 aas and 3 TMSs.	Bacteria	Pseudomonadota	Hol of Citrobacter sp. TSA-1
1.E.5.2.7	Phage holin family protein of 138 aas and 3 TMSs in a 1 + 2 TMS arrangement.	Bacteria	Pseudomonadota	Holin of Marinomonas shanghaiensis
1.E.5.2.8	Holin, HolY of 103 aas and 3 TMSs. It is found in a holin-endolysin cassette in Y. enterocolitica, and has been adapted via evolution to export a large bacterial toxin (Sänger et al. 2023).	Bacteria	Pseudomonadota	HolY of Yersinia enterocolitica
1.E.5.2.9	Holin, Stm0015, of 114 aas and 3 TMSs. This holin, together with a peptidoglycan hydrolase, Stm0016, comprises a secretion system (type 10) for an exo-chitinase of 699 aas (Stm0018) (partially homologous to the protein listed under TC# 9.B.29.2.7 (Chi1)).	Archaea	Thermoproteota	Holin of Salmonella enterica (subsp. Typhimurium)
1.E.5.3.1	Uncharacterized protein	Bacteria	Thermodesulfobacteriota	Uncharacterized protein of Desulfovibrio vulgaris
1.E.5.3.2	Putative holin	Bacteria	Synergistota	Putative holin of Aminobacterium colombiense
1.E.5.3.3	Uncharacterized protein	Bacteria	Synergistota	Uncharacterized protein of Dethiosulfovibrio peptidovorans
1.E.5.3.4	Putative holin	Bacteria	Synergistota	Putative holin of Jonquetella anthopi
1.E.5.3.5	Putative holin	Bacteria	Synergistota	Putative holin of Pyramidobacter piscolens
1.E.5.4.1	Phage holin family protein of 108 aas and 3 TMSs.	Bacteria	Pseudomonadota	Holin of Rhizobium sp.
1.E.5.4.2	Phage holin family protein of 108 aas and 2 or 3 TMSs.	Bacteria	Pseudomonadota	Holin of Chitinibacter tainanensis
1.E.5.4.3	Phage holin family protein of 111 aas and 3 TMSs.	Bacteria	Pseudomonadota	Holin of Azospirillum oryzae
1.E.5.4.4	Phage holin family protein of 117 aas and 3 TMSs.	Bacteria	Pseudomonadota	Holin of Elstera litoralis
1.E.5.4.5	Putative holin of 117 aas and 3 TMSs.	Bacteria	Pseudomonadota	Holin of Halomonas qiaohouensis
1.E.5.4.6	Uncharacterized putative holin protein of 108 aas and 3 TMSs.	Bacteria	Pseudomonadota	UP of Parvibaculum sp.
1.E.5.4.7	Uncharacterized putative holin of 121 aas and 3 TMSs.	Bacteria	Pseudomonadota	UP of Hoeflea sp.
1.E.5.5.1	Holin of 96 aas with 3 TMSs.	Viruses	Heunggongvirae, Uroviricota	Holin of Serratia phage Serbin