| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.E.8.1.1 | Lysis protein, T, of 218 aas and 1 TMS. T holin activity is regulated by the largely periplasmic anti-holin RI (P13304) and the cytoplasmic antiholin R3 (P17309) which act synergistically (Chen and Young 2016). RI is degraded by DegP (Tran et al., 2007). Mutations in all 3 topological domains if RI (the N-terminal cytoplasmic domain, the single TMS, and the C-terminal periplasmic domain) can abrogate holin function (Moussa et al. 2014). The short cytoplasmic region of phage T4 holin is essential for the transition from impermeable membrane protein complexes to permeable pores (Schwarzkopf et al. 2025). | None |
Heunggongvirae, Uroviricota | Lysis protein or holin (P06808) of Phage T4 |
|
1.E.8.1.2 | Viruses |
Heunggongvirae, Uroviricota | T-holin of phage RB43 | |
|
1.E.8.1.3 | Putative holin of 208 aas and 1 TMS. | Viruses |
Heunggongvirae, Uroviricota | Holin of pectobacterial phage My1 |
|
1.E.8.1.4 | Putative holin (lysis protein) of enterobacterial phage T5 (218 aas; 1 TMS) (Catalão et al. 2012). | Viruses |
Heunggongvirae, Uroviricota | Putative holin of phage T5 |
|
1.E.8.1.5 | T holin lysis mediator of 215 aas and 1 TMS. Phage KP27 protects against multidrug resistant strains of Klebsiella (Maciejewska et al. 2016). | Viruses |
Heunggongvirae, Uroviricota | Holin of Klebsiella phage KP27 |
|
1.E.8.1.6 | Holin of 240 aas and 2 N-terminal TMSs. It interacts (via its C-terminus) with antiholin (via its C-terminus); this interaction blocks the holin homomultimerization and delays host cell lysis. It also interacts (via its N-terminus) with the lysis inhibition accessory protein rIII; this interaction stabilizes the holin-antiholin complex thereby resulting in a robust block of the hole formation. | Viruses |
Heunggongvirae, Uroviricota | Holin of Acinetobacter phage AbTZA1 |