1.F.1.2.3
E3 ubiquitin-protein ligase, Tripartite motif 11, TRIM11, of 468 aas and possibly 1 C-terminal TMS.  It disaggregates and degrades misfolded tau.  In Alzheimer's disease and other taupathies, tau protein misfolds and forms oligomers, which clump together to form filamentious aggregates.  TRIM11 breaks up these aggregates and facilitates the proteasomal degradation of misfolded tau (Noble and Hanger 2023).  TRIM11 is down regulated in Alzheimer's disease, and up-regulation helps to reverse the symptoms of Alzheimer's diseease. Upon overexpression, TRIM11 reduces HIV-1 and murine leukemia virus infectivity by suppressing viral gene expression (Uchil et al. 2008).