1.F.1.3.2
Vesicle-associated membrane protein 7, VAMP7, of 220 aas and 2 TMSs, N- and C-terminal. It is involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Iy is required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis, and involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation (Braun et al. 2004). VAMP7j is a splice variant of human VAMP7 that modulates neurite outgrowth by regulating L1CAM transport to the plasma membrane (Gasparotto et al. 2023).