1.F.3.1.4
Guanine nucleotide exchange factor, VAV2, of 878 aas and possibly 3 TMSs in a 1 (N-terminus) + 2 TMSs (residues 220 - 280). VAV2 is a factor for the Rho family of Ras-related
GTPases. It plays a role in angiogenesis. Its recruitment by
phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase
activation and vascular endothelial cell migration and assembly. Vav2 is also an amyloid precursor protein (APP)-interacting protein that regulates APP protein levels (Zhang et al. 2022). APP has TC# 1.C.50.1.2.
|
| Accession Number: | P52735 |
|---|
| Protein Name: | Guanine nucleotide exchange factor VAV2 |
|---|
| Length: | 878 |
|---|
| Molecular Weight: | 101289.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Substrate |
|
|---|
1: MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI
61: NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI
121: AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV
181: QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV
241: FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL
301: LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK
361: EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH
421: TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY
481: LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC
541: KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN
601: PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR
661: PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI
721: KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR
781: SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG
841: DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ