1.G.18.1.1
The SARS-CoV has two fusion peptides, one of 19 aas (residues 770 - 788) and the other of 16 aas (residues 873 - 888) in the spike glycoprotein precursor of 1255 aas (Apellániz et al. 2014). The structure of a 34 aa fusion peptide has been determined (PDB 1ZVB). The very hydrophobic C-terminal TMS also appears to be required for fusion (Aliper and Efremov 2023). The Spike (S) glycoprotein cytoplasmic domain is palmitoylated and that palmitoylation has two membrane proximal cysteine clusters I and II that are important for S-mediated cell fusion (Petit et al. 2007). The SARS-CoV E protein has transmembrane domains that increase the mamalian cell membrane permeability (Liao et al. 2006).
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| Accession Number: | D3KDM5 |
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| Protein Name: | Spike glycoprotein |
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| Length: | 1255 |
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| Molecular Weight: | 139137.00 |
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| Species: | SARS coronavirus HKU-39849 [228404] |
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| Number of TMSs: | 1 |
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| Substrate |
molecule |
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1: MFIFLLFLTL TSGSDLDRCT TFDDVQAPNY TQHTSSMRGV YYPDEIFRSD TLYLTQDLFL
61: PFYSNVTGFH TINHTFGNPV IPFKDGIYFA ATEKSNVVRG WVFGSTMNNK SQSVIIINNS
121: TNVVIRACNF ELCDNPFFAV SKPMGTQTHT MIFDNAFNCT FEYISDAFSL DVSEKSGNFK
181: HLREFVFKNK DGFLYVYKGY QPIDVVRDLP SGFNTLKPIF KLPLGINITN FRAILTAFSP
241: AQDIWGTSAA AYFVGYLKPT TFMLKYDENG TITDAVDCSQ NPLAELKCSV KSFEIDKGIY
301: QTSNFRVVPS GDVVRFPNIT NLCPFGEVFN ATKFPSVYAW ERKKISNCVA DYSVLYNSTF
361: FSTFKCYGVS ATKLNDLCFS NVYADSFVVK GDDVRQIAPG QTGVIADYNY KLPDDFMGCV
421: LAWNTRNIDA TSTGNYNYKY RYLRHGKLRP FERDISNVPF SPDGKPCTPP ALNCYWPLND
481: YGFYTTTGIG YQPYRVVVLS FELLNAPATV CGPKLSTDLI KNQCVNFNFN GLTGTGVLTP
541: SSKRFQPFQQ FGRDVSDFTD SVRDPKTSEI LDISPCSFGG VSVITPGTNA SSEVAVLYQD
601: VNCTDVSTAI HADQLTPAWR IYSTGNNVFQ TQAGCLIGAE HVDTSYECDI PIGAGICASY
661: HTVSLLRSTS QKSIVAYTMS LGADSSIAYS NNTIAIPTNF SISITTEVMP VSMAKTSVDC
721: NMYICGDSTE CANLLLQYGS FCTQLNRALS GIAAEQDRNT REVFAQVKQM YKTPTLKYFG
781: GFNFSQILPD PLKPTKRSFI EDLLFNKVTL ADAGFMKQYG ECLGDINARD LICAQKFNGL
841: TVLPPLLTDD MIAAYTAALV SGIATAGWTF GAGAALQIPF AMQMAYRFNG IGVTQNVLYE
901: NQKQIANQFN KAISQIQESL TTTSTALGKL QDVVNQNAQA LNTLVKQLSS NFGAISSVLN
961: DILSRLDKVE AEVQIDRLIT GRLQSLQTYV TQQLIRAAEI RASANLAATK MSECVLGQSK
1021: RVDFCGKGYH LMSFPQAAPH GVVFLHVTYV PSQERNFTTA PAICHEGKAY FPREGVFVFN
1081: GTSWFITQRN FFSPQIITTD NTFVSGNCDV VIGIINNTVY DPLQPELDSF KEELDKYFKN
1141: HTSPDVDLGD ISGINASVVN IQKEIDRLNE VAKNLNESLI DLQELGKYEQ YIKWPWYVWL
1201: GFIAGLIAIV MVTILLCCMT SCCSCLKGAC SCGSCCKFDE DDSEPVLKGV KLHYT