1.G.18.1.6
Surface glycoprotein of 1273 aas and at least two TMSs, N- and C-terminal, but several smaller peaks of hydrophobicity that could be TMSs occur inbetween these two. Wrapp et al. 2020. Cai et al. 2020 determined a 3.5-Å-resolution cryo-EM structure
of the 2019-nCoV S trimer in the prefusion conformation. The predominant
state of the trimer has one of the three receptor-binding domains
(RBDs) rotated up in a receptor-accessible conformation. They also provided
biophysical and structural evidence that the 2019-nCoV S protein binds
angiotensin-converting enzyme 2 (ACE2) with higher affinity than does
severe acute respiratory syndrome (SARS)-CoV S. report two cryo-electron microscopy structures derived from a
preparation of the full-length S protein, representing its prefusion
(2.9-angstrom resolution) and postfusion (3.0-angstrom resolution)
conformations, respectively. The spontaneous transition to the
postfusion state is independent of target cells. The prefusion trimer
has three receptor-binding domains clamped down by a segment adjacent to
the fusion peptide. The postfusion structure is strategically decorated
by N-linked glycans, suggesting possible protective roles against host
immune responses and harsh external conditions (Cai et al. 2020).
|
| Accession Number: | YP_009724390 |
|---|
| Protein Name: | YP_009724390.1 surface glycoprotein [Severe acute respiratory syndrome coronavirus 2] |
|---|
| Length: | 1274 |
|---|
| Molecular Weight: | |
|---|
| Species: | Severe acute respiratory syndrome coronavirus 2 [2697049] |
|---|
| Number of TMSs: | 1 |
|---|
| Substrate |
|
|---|
1: MFVFLVLLPL VSSQCVNLTT RTQLPPAYTN SFTRGVYYPD KVFRSSVLHS TQDLFLPFFS
61: NVTWFHAIHV SGTNGTKRFD NPVLPFNDGV YFASTEKSNI IRGWIFGTTL DSKTQSLLIV
121: NNATNVVIKV CEFQFCNDPF LGVYYHKNNK SWMESEFRVY SSANNCTFEY VSQPFLMDLE
181: GKQGNFKNLR EFVFKNIDGY FKIYSKHTPI NLVRDLPQGF SALEPLVDLP IGINITRFQT
241: LLALHRSYLT PGDSSSGWTA GAAAYYVGYL QPRTFLLKYN ENGTITDAVD CALDPLSETK
301: CTLKSFTVEK GIYQTSNFRV QPTESIVRFP NITNLCPFGE VFNATRFASV YAWNRKRISN
361: CVADYSVLYN SASFSTFKCY GVSPTKLNDL CFTNVYADSF VIRGDEVRQI APGQTGKIAD
421: YNYKLPDDFT GCVIAWNSNN LDSKVGGNYN YLYRLFRKSN LKPFERDIST EIYQAGSTPC
481: NGVEGFNCYF PLQSYGFQPT NGVGYQPYRV VVLSFELLHA PATVCGPKKS TNLVKNKCVN
541: FNFNGLTGTG VLTESNKKFL PFQQFGRDIA DTTDAVRDPQ TLEILDITPC SFGGVSVITP
601: GTNTSNQVAV LYQDVNCTEV PVAIHADQLT PTWRVYSTGS NVFQTRAGCL IGAEHVNNSY
661: ECDIPIGAGI CASYQTQTNS PRRARSVASQ SIIAYTMSLG AENSVAYSNN SIAIPTNFTI
721: SVTTEILPVS MTKTSVDCTM YICGDSTECS NLLLQYGSFC TQLNRALTGI AVEQDKNTQE
781: VFAQVKQIYK TPPIKDFGGF NFSQILPDPS KPSKRSFIED LLFNKVTLAD AGFIKQYGDC
841: LGDIAARDLI CAQKFNGLTV LPPLLTDEMI AQYTSALLAG TITSGWTFGA GAALQIPFAM
901: QMAYRFNGIG VTQNVLYENQ KLIANQFNSA IGKIQDSLSS TASALGKLQD VVNQNAQALN
961: TLVKQLSSNF GAISSVLNDI LSRLDKVEAE VQIDRLITGR LQSLQTYVTQ QLIRAAEIRA
1021: SANLAATKMS ECVLGQSKRV DFCGKGYHLM SFPQSAPHGV VFLHVTYVPA QEKNFTTAPA
1081: ICHDGKAHFP REGVFVSNGT HWFVTQRNFY EPQIITTDNT FVSGNCDVVI GIVNNTVYDP
1141: LQPELDSFKE ELDKYFKNHT SPDVDLGDIS GINASVVNIQ KEIDRLNEVA KNLNESLIDL
1201: QELGKYEQYI KWPWYIWLGF IAGLIAIVMV TIMLCCMTSC CSCLKGCCSC GSCCKFDEDD
1261: SEPVLKGVKL HYT