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1.G.2 The Viral Pore-forming Membrance Fusion Protein-2 (VMFP2) Family

Like the Influenza HA protein, the Paramyxovirus F protein is of Class I (White et al. 2008) and shares the characteristics noted in the description for family 1.H.1. It is the second best charaterized Class I viral fusion protein. The crystal structures of various ectodomains are known. The F protein consists of three domains, domains, I, II, and III (Lamb and Jardetzky, 2007).

References associated with 1.G.2 family:

Apellaniz B., Huarte N., Largo E. and Nieva JL. (2014). The three lives of viral fusion peptides. Chem Phys Lipids. 181:40-55. 24704587
Cifuentes-Mu├▒oz, N., W. Sun, G. Ray, P.T. Schmitt, S. Webb, K. Gibson, R.E. Dutch, and A.P. Schmitt. (2017). Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly. J. Virol. 91:. 28468881
Coropceanu, I., E.M. Janke, J. Portner, D. Haubold, T.D. Nguyen, A. Das, C.P.N. Tanner, J.K. Utterback, S.W. Teitelbaum, M.H. Hudson, N.A. Sarma, A.M. Hinkle, C.J. Tassone, A. Eychm├╝ller, D.T. Limmer, M. Olvera de la Cruz, N.S. Ginsberg, and D.V. Talapin. (2022). Self-assembly of nanocrystals into strongly electronically coupled all-inorganic supercrystals. Science 375: 1422-1426. 35324292
Crampon, E., E. Covernton, M.C. Vaney, M. Dellarole, S. Sommer, A. Sharma, A. Haouz, P. England, J. Lepault, S. Duquerroy, F.A. Rey, and G. Barba-Spaeth. (2023). New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex. mBio e0070623. [Epub: Ahead of Print] 37607061
Lamb, R.A. and T.S. Jardetzky. (2007). Structural basis of viral invasion: lessons from paramyxovirus F. Curr. Opin. Struct. Biol. 17: 427-436. 17870467
Li Z., Hung C., Paterson RG., Michel F., Fuentes S., Place R., Lin Y., Hogan RJ., Lamb RA. and He B. (2015). Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion. Proc Natl Acad Sci U S A. 112(40):12504-9. 26392524
McLellan, J.S., M. Chen, S. Leung, K.W. Graepel, X. Du, Y. Yang, T. Zhou, U. Baxa, E. Yasuda, T. Beaumont, A. Kumar, K. Modjarrad, Z. Zheng, M. Zhao, N. Xia, P.D. Kwong, and B.S. Graham. (2013). Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 340: 1113-1117. 23618766
Saier, M.H., Jr, V.S. Reddy, B.V. Tsu, M.S. Ahmed, C. Li, and G. Moreno-Hagelsieb. (2016). The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res 44: D372-379. 26546518
von Messling, V., D. Milosevic, P. Devaux, and R. Cattaneo. (2004). Canine distemper virus and measles virus fusion glycoprotein trimers: partial membrane-proximal ectodomain cleavage enhances function. J. Virol. 78: 7894-7903. 15254162
White, J.M., S.E. Delos, M. Brecher, and K. Schornberg. (2008). Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Crit. Rev. Biochem. Mol. Biol. 43: 189-219. 18568847
Yao, H., M. Lee, S.Y. Liao, and M. Hong. (2016). Solid-State NMR Investigation of the Structural Topology and Lipid Interactions of a Viral Fusion Protein Chimera Containing the Fusion Peptide and Transmembrane Domain. Biochemistry. [Epub: Ahead of Print] 27766858