1.G.20.1.4
The envelopment polyprotein, GP, of 1441 aas and 8 TMSs in a 1 (N-terminal) + 2 +4 + 1 (C-terminal) TMS arrangement. The precursor protein is processed to the glycoprotein (C-terminal) and glycoprotein (N-terminal) which interact with
each other and are present at the surface of the virion. They are able
to attach the virion to a cell receptor and to promote fusion of
membranes after endocytosis of the virion (Plassmeyer et al. 2005; Pekosz et al. 1995; Hulswit et al. 2021).
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| Accession Number: | P09612 |
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| Protein Name: | Envelopment polyprotein |
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| Length: | 1441 |
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| Molecular Weight: | 162541.00 |
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| Species: | Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974) [11578] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Host Golgi apparatus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MIRMLVLIVV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT EARYVKNATG
61: VFSNNVAIRK WLVSDWHDCR PKKIVGGHIN VIEVGDDLSL HTESYVCSAD CTIGVDKETA
121: QVRLQTDTTN HFEIAGTTVK SGWFKSTTYI TLDQTCEHLK VSCAPKSVQF HACFNQHMSC
181: VRFLHRTILP GSIANSICQN IEIIILVTLT LLIFILLSIL SKTYICYLLM PIFIPIAYMY
241: GVIYNKSCKK CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV
301: MCKSKGPASI LSIITAVLVL TFVTPINSMV LGESKETFEL EELPDDMLEM ALRINSYYFT
361: CILNYAVSWG LIIAGLLVGL IFKKYQHRFL NIYAMYCEEC NMYHDKSGLK RHGDFTNKCR
421: QCTCGQYEDA TGLITHRKTY NCLVQYKAKW MMNFLIIYIF LILIKDSAIV GQATGTDFTT
481: CLETESINWN CTGPFLNLGN CQKQQKKEPY TNIATQLKGL KAISVLDIPI ITSIPDDIAG
541: ALRYIEEKED FHVQLTTEYA MLSKYCDYYT QFSDNSGYSQ TTWRVYLRSH DFEACILYPN
601: QHFCKCVKNG EKCSSSNWDF ANGMKNYYSG KQAKFDKDLN LALTALHHAF RGTSSAYIAA
661: MLSKKSNDDL IAYTNKIKAK FPGNALLKAI IDYIAYMKGL PEMANFKYDE FWDELLYKPN
721: PAKASNLARG KESSYNFKLA ISSKSIKTCK NVKDVACLSP RSGAIYSSII ACGEPNGPSV
781: YRKPSGGVFQ SSTDRSIYCL LDSHCLEEFE AISQEELDAV KKSKCWEIEY PDVRPLQESD
841: GAKSCRMKDS GNCNVATNRW PVMQCENDKF YYSELQKDYD KTQDIGHYCL SPGCTTIRYP
901: INPKHISNCN WQVSRSSIAK IDVHNVEDIE QYKKAITQKL QTSLSLFKYA KTKNLPHIRP
961: IYKYITMKET ETAEGIESAY IESEVPALAG TSVGFKINSK EGKHLLDVIA YVKSASYSSV
1021: YAKLYSTGPT SGINTKHDEL CTGPCPANIN HQVGWLTFAR ERTSSWGCEE FGCLAVSDGC
1081: VFGSCQDIIK EELSVYRKET EEVTNVELCL TFSDKTYCTN LNPVTPIITD LFEVQFKTVE
1141: TYSLPRIVAV QNHEIKIGQI NDLGVYSKGC GNVQKVNGTV YGNGVPRFDY LCHLASRKEV
1201: IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTIIDYKKIL GTIKMKAILG DVKYKTFADS
1261: VDITAEGSCA GCINCFQNIH CELTLHTTIE ASCPIKSSCT VFHDRILVTP NEHKYALKIV
1321: CTEKPGNTLT IKVCNTRIEA SMALVDAKPI IELAPVDQTA YIREKDERCK TWMCRVRDEG
1381: LQVILEPFKN LFGSYIGIFY TFIISIIALL VIIYVLLPIC FKLRDTLRKH DDAYKREMKI
1441: R