1.G.20.2.1
Envelope glycoprotein of 1684 aas and 5 - 8 TMSs, Env-GP, including Gn and Gc (Xiao et al. 2011). Blocking transport out of multivesicular bodies still allowed virus entry while preventing vesicular acidification, required for membrane fusion, trapping virions in the MVBs (Shtanko et al. 2014). Entry is dependent on the CCHFV envelope GP (Suda et al. 2016).
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| Accession Number: | Q66034 |
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| Protein Name: | Envelope glycoprotein |
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| Length: | 1684 |
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| Molecular Weight: | 186679.00 |
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| Species: | Crimean-Congo hemorrhagic fever virus [11593] |
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| Number of TMSs: | 5 |
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| Substrate |
molecule |
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1: MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTHGD NPSSEPPVST ALSITLDPST
61: VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT GTDTLSAGDV DPSTQTAGGT
121: SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL SVTSPGPDET STPSGTGKES SATSSPHPVS
181: NRPPTPPATA QGPTENDSHN ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS
241: PTNRSKRNLK MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF
301: QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG FLSIDSGYYS
361: AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC INLKASIFKE HREVEINVLL
421: PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR LPHIYHEGVF IPGTYKIVID KKNKLNDRCT
481: LFTDCVIKGR EVRKGQSVLR QYKTEIRIGK ASTGFRRLLS EEPSDDCVSR TQLLRTETAE
541: IHGDNYGGPG DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV
601: KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC SGGQQHFLKD
661: NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG YVITCILCKA IFYLLIIVGT
721: LGRRLKQYRE LKPQTCTICE TTPVNAIDAE MHDLNCSYNI CPYCASRLTS DGLARHVIQC
781: PKRKEKVEET ELYLNLERIP WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA
841: PIGQGKTIEA YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS
901: SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKTGSNVML AVCKLMCFRA
961: TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN LPAGTWEREE DLTNFCHQEC
1021: QVTETECLCP YEALVLRKPL FLDSTAKGMK NLLNSTSLET SLSIEAPWGA INVQSTYKPT
1081: VSTANIALSW SSVEHRGNKI LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL
1141: SQMYSPVFEY LSGDRQVEEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG
1201: VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE AGTRFNLGPV
1261: TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS ASTVCKLQSC THGVPGDLQV
1321: YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS
1381: FVNLLNIETD YTKNFHFHSK RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI
1441: EISGLKFASL ACTGCYACSS SISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE
1501: FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI LIEHKGTIIG
1561: KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF LFLAPFILLI LFFMFGWRIL
1621: FCFKCCRRTR GLFKYRHLKD DEETGYRRII EKLNNKKGKN KLLDGERLAD GRIAELFSTK
1681: THIG