1.G.22.1.2
Rhesus cytomegalovirus glycoprotein B of 854 aas and 3 TMSs, 1 N-terminal and 2 near the C-terminus of the protein. GpB is an envelope glycoprotein that forms spikes at the surface of virion
envelope. It is essential for the initial attachment to heparan sulfate
moieties of the host cell surface proteoglycans and is involved in fusion of
viral and cellular membranes leading to virus entry into the host cell.
Following initial binding to its host receptors, membrane fusion is
mediated by the fusion machinery composed at least of gB and the
heterodimer gH/gL. It may be involved in the fusion between the virion
envelope and the outer nuclear membrane during virion egress (Yue et al. 2003).
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| Accession Number: | P89053 |
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| Protein Name: | Envelope glycoprotein B |
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| Length: | 854 |
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| Molecular Weight: | 97826.00 |
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| Species: | Rhesus cytomegalovirus (strain 68-1) (RhCMV) [103930] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Virion membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MSKNWFPLLC ASVLVVYVSI ASSSTGTASG AVTPTSPTEN TTGPLIENTT LRTHEVFKIN
61: MSKFPYRVCS MAQGTDLLRF EQNINCDSFK PTKEDFEEGI MVVYKRDIRP YTFKVHMYQK
121: ILTFRQSYSF IRENHLLGFS QEHLAVPMWE VHYINKLNRC YNSVVRNVAG ATYVNYHRDS
181: YVNETMLLVE DDFSNTHSSR FVTVKELWHK PGSTWLYTTS CNVNCMVTVT TARSKYPYDF
241: FVTSDGKVVD ISPFYNGSNN KHFGENRDKF SVRKNYSMIA YYGRDNAPEV AHPLVGFFER
301: PDVLMSWDIV EEANNTCEYT FWEQSERTIR SEADDTYHYT SSSMTATFLT SKEELNESDP
361: SFQCIKDKAN EQLQLIFNTS YNETYVQSGN VSMYETTGGL IVFWLPVKEK SILEMEELAV
421: AYNNTNSSTR RKRSTDSASD SNKTSEEVLK SIVYAQLQYT YDTLRNYINR ALRQIAEAWC
481: KDQKRTLEVF KELSKINPSA MLSAIYDKPI AARFVGDVIS LAKCVEVDQN SVKVLRDMRT
541: KESGVCYSRP VVLYTFKNSS HVQYGQLGEY NEILLGRHRT EACEYPSLKI YIAGNSSYEY
601: VDYLYKRMIP LDSISTVDTM ISLDIDPLEN TDFKALELYS EDELRSSNVF DLEDIMREFN
661: TYKQRMIHVE GKVFDKVPGY LRGLDDMMSG LGSAGKALGV AIGAVGGAVA SFVEGVVGFI
721: KNPFGSFTVI LFLLAVLGVI YLIYMRQKRA YEKPFEHFFP YVVPPTTVKE APPSYEQSQY
781: ENIKEKAASA TKEFSLEEAY QMLLALQKLD QEKRRKAEAD DEDFASNGQS AGFLDRLRNR
841: RRGGYQKIQN EYEV