Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.H.1.1.15
Claudin-3 (CLDN3) of 220 aas.  Forms homooligomers as well as heterooligomers with CLNVN1 (Milatz et al. 2015). Also forms hetero-oligomers with Claudin-16 and Claudin-19 which are divalent cation (Ca2+ and Mg2+)-selective (Milatz et al. 2017). The crystal structure of claudin-3 at 3.6 A resolution reveals that the third TMS is bent compared with that of other subtypes, and strand formation - straight or curvy strands - observed in native epithelia results in different morphologies (Nakamura et al. 2019). .

Accession Number:O15551
Protein Name:Claudin-3
Length:220
Molecular Weight:23319.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1
Substrate calcium(2+), magnesium(2+)

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ 
61:	MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 
121:	GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 
181:	CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV