1.H.1.1.16
Claudin 5 of 218 aas and 4 TMSs.  Plays an important role in the tight junctions that comprise the blood-brain barrier (BBB) (Irudayanathan et al. 2015). Polyinosinic-polycytidylic acid [Poly(I:C)], a synthetic analog of viral double-stranded RNA (dsRNA) commonly used to simulate viral infections, decreases the expression of claudin-5, and gives rise to increased endothelial permeability (Huang et al. 2016). DNA methylation plays an important role in regulating BBB repair after stroke, through regulating processes associated with BBB restoration and prevalently with processes enhancing BBB injury (Phillips et al. 2023). It may have 4 C-terminal TMSs. Wine-processed Chuanxiong Rhizoma enhances efficacy of aumolertinib against EGFR mutant non-small cell lung cancer xenografts in nude mouse brain (Niu et al. 2023).