1.H.1.1.19
Claudin-9, CLDN9, of 217 aas and 4 or 5 TMSs. It plays a major role in tight junction-specific obliteration of the
intercellular space, through calcium-independent cell-adhesion activity. It acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. It's expression in breast cancer has been evaluated, and its signifucabce with respect to its impact on drug resistance has been reported (Zhuang et al. 2023).
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| Accession Number: | O95484 |
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| Protein Name: | Claudin-9 |
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| Length: | 217 |
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| Molecular Weight: | 22848.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 |
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| Substrate |
ion |
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1: MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL WMSCVVQSTG
61: QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGLLVAIT GAQCTTCVED EGAKARIVLT
121: AGVILLLAGI LVLIPVCWTA HAIIQDFYNP LVAEALKREL GASLYLGWAA AALLMLGGGL
181: LCCTCPPPQV ERPRGPRLGY SIPSRSGASG LDKRDYV