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1.H.1.1.8
PM22_Claudin family (CLDN_18A2.1; CRA_C; 264 aas). It is 88% identical to the human ortholog, CLDN18 of 261 aas and 4 TMSs (P56856). The human CLDN18.1 attenuates malignant properties including xenograft tumor growth in vivo as well as cell proliferation, migration, invasion and anchorage-independent colony formation in vitro (Luo et al. 2018). A transmembrane scaffold from CD20 helps recombinant expression of a chimeric claudin 18.2 in an in vitro coupled transcription and translation system (Wang et al. 2024).

Accession Number:P56857
Protein Name:Claudin-18A2.1 aka Cldn18
Length:264
Molecular Weight:28122.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate ion

Cross database links:

RefSeq: NP_062789.1   
Entrez Gene ID: 56492   
Pfam: PF00822   
KEGG: mmu:56492   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0042802 F:identical protein binding
GO:0005198 F:structural molecule activity
GO:0016338 P:calcium-independent cell-cell adhesion

References (2)

[1] “Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.”  Niimi T.et.al.   11585919
[2] “Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.”  Dai J.et.al.   17203969

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW RSCVQQSSGF 
61:	TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT 
121:	SGILFIISGI CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MGGMVQTVQT RYTFGAALFV 
181:	GWVAGGLTLI GGVMMCIACR GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN 
241:	KKIYDGGART EDDEQSHPTK YDYV