1.H.1.4.6
Ecm7, (448aas; 4 TMS), is a member of the PMP-22/EMP/MP20 Claudin
superfamily of transmembrane proteins that includes gamma-subunits of
voltage-gated calcium channels. It appears to interact with Mid1 and
regulate the activity of the Cch1/Mid1 channel (TC# 1.A.1.11.10; Martin et al., 2011). Ecm7p is related to members of TC families 1.H.1, 1.H.2 and 1.A.81.
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| Accession Number: | Q06200 |
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| Protein Name: | Protein ECM7 |
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| Length: | 448 |
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| Molecular Weight: | 50328.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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1: MVMSRIRDTI ARPFQNLTAL EKVVQWLRLG TTLLIISFGL ALTVGPLSSP RTLYMSRLDT
61: YSADITTGLF TVLRESMEQS TSTEENNGVG LTTSELYILT AYTESQIKNV PQYITVSLYG
121: RCDSTYTMVE VFDSEGNMHS VKNSTTKSTC SSIGTDYLFD YREVLESLGL DIILDYAYNK
181: IGSQQAESSA YTTYMRSLKH KKANVLHLLY AVISFQVCML FFMIWYYYIK GRFMNALKER
241: ALVHINSLLS LVVFIGGLIS SISLAWVNYT IQSRINTELE AFGFSYHLGV TWFALLWCFA
301: GLISVSCLAW SGLEWCISDN GTSYGGGIDD KFLGYQAGVF TDADLDDETS YSQRYPQRQS
361: TSGEAELMRN SDTMATIRKT SDVDLNSEND ANTSLDHGNP TANISNGGKH EPFATREEFE
421: LQDIRFRSSN DSEESMQRVI KPSSALQF