TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.H.3.1.1









Amastin of 174 aas and 4 TMSs in a 1 + 3 TMS arrangement as is typical of members of the Amastin family (Slathia and Sharma 2018).

Eukaryota
Euglenozoa
Amastin of Trypanosoma cruzi
1.H.3.1.2









Amastin-like protein of 456 aas and 4 C-terminal TMSs in a 1 + 3 TMS arrangement.

Eukaryota
Euglenozoa
Amastin of Trypanosoma brucei
1.H.3.1.3









Amastin-like protein of 221 aas and 4 TMSs in a 1 + 3 TMS arrangement.

Eukaryota
Euglenozoa
Amastin-like protein of Leishmania braziliensis
1.H.3.1.4









Large amastin-like protein of 461 aas and 10 TMSs in a 2 + 1 + 4 + 3 TMS arrangement.  This protein may have 2 N-terminal TMSs followed by two 4-TMS Amastin-like domains. The last 4 TMSs show the greatest sequence similarity with shorter amastins.

Eukaryota
Euglenozoa
Large mmastin-like protein of Trypanosoma cruzi
1.H.3.1.5









Putative amastin-like surface protein of 262 aas and 5 or 6 TMSs in a 2 + 3 or 3 + 3 TMS arrangement, respectively.

Eukaryota
Euglenozoa
Amastin-like protein of Leishmania major
1.H.3.1.6









Amastin-like protein of 203 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement.

Eukaryota
Euglenozoa
Amastin-like protein of Leishmania braziliensis
1.H.3.1.7









Uncharacterized protein of 331 aas and 7 TMSs in a 2 + 2 + 2 + 1 TMS arrangement.

Euglenozoa
UP of Angomonas deanei
1.H.3.1.8









Amastin-like protein of 380 aas and 8 TMSs in a 1 + 4 + 3 TMS arrangement, possibly with two tandem amastin-like domains.

Eukaryota
Euglenozoa
Internally duplicated amastin domains in Bodo saltans
1.H.3.1.9









Putative amastin protein of 431 aas and 9 TMSs in a 2 + 2 + 2 + 2 + 1 TMS arrangement.

Eukaryota
Euglenozoa
Amastin-like protein of Phytomonas sp.
1.H.3.1.10









Uncharacterized protein of 270 aas and 4 distant TMSs in an apparent 2 + 2 TMS arrangement.

Eukaryota
Euglenozoa
UP of Strigomonas culicis
1.H.3.1.11









Uncharacterized protein of 199 aas and 4 TMSs in a 21 + 3 TMS arrangement.

Eukaryota
Euglenozoa
UP of Leishmania guyanensis
1.H.3.1.12









g-amastin of 216 aas and 4 TMSs in a 1 + 2 + 1 arrangement.

Eukaryota
Euglenozoa
g-Amastin of Crithidia sp.
1.H.3.1.13









Amastin-like protein of 250 aas and 4 TMSs in a 1 _ 2 + 1 TMS arrangement.

Eukaryota
Euglenozoa
Amastin-like surface protein of Angomonas deanei
1.H.3.1.14









Amastin-like protein of 249 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement.

Eukaryota
Euglenozoa

Amastin protein of Leptomonas pyrrhocoris
1.H.3.1.15









Uncharacterized protein of 190 aas and 4 TMSs

Eukaryota
Euglenozoa
UP of Trypanosoma conorhini
1.H.3.1.16









Uncharacterized protein of 194 aas and 4 TMSs in a 1 + 3 TMS arrangement.

Eukaryota
Fungi, Basidiomycota
UP of Saitozyma podzolica
1.H.3.1.17









Uncharacterized protein of 490 aas and 8 TMSs in a 1 + 3 + 1_ 2 + 1 TMS arrangement. This protein belongs to the Pfam family, PF02681 and the PAP2 (CL0525) clan.

Eukaryota
Euglenozoa
UP of Leishmania major
1.H.3.1.18









Amastin protein, TryB2, of 299 aas with a hydrophilic N-terminal domain followed by a 4 TMS .domain.

Eukaryota
Euglenozoa
Amastin of Trypanosoma brucei brucei
1.H.3.1.19









Amastin protein of 183 aas and 4 TMSs.

Eukaryota
Euglenozoa
Amastin of Leishmania donovani  
1.H.3.2.1









Uncharacterized pali-domain containing protein of 523 aas and 4 TMSs at the N-terminus of the protein in a 1 + 3 TMS arrangement with a long C-terminal hydrophilic domain.

Eukaryota
Fungi, Ascomycota
UP of Suhomyces tanzawaensis
1.H.3.2.2









Uncharacterized protein of 580 aas and 4 TMSs in a 1 + 3 arrangement with a long C-terminal hydrophilic domain.

Eukaryota
Fungi, Ascomycota
UP of Candida parapsilosis
1.H.3.2.3









Uncharacterized protein of 553 aas and 4 TMSs in a 1 + 3 TMs arrangement followed by a long hydrophilic domain.

Eukaryota
Fungi, Ascomycota
UP of Clavispora lusitaniae
1.H.3.2.4









Putative pH signal transduction protein PalI of 561 aas and 4 N-terminal TMSs in a 1 + 3 TMS arrangement followed by a large hydrophilic domain.

Fungi, Ascomycota
PalI protein of Aspergillus flavus
1.H.3.2.5









Uncharacterized protein of 231 aas and 4 TMSs in a 1 + 3 TMS arrangement.

Eukaryota
Fungi, Ascomycota
UP of Venustampulla echinocandica
1.H.3.2.6









Uncharacterized protein of 309 aas and 4 TMSs in a 1 + 3 TMs arrangement with a C-terminal hydrophilic domain.

Eukaryota
Fungi, Ascomycota
UP of Komagataella pastoris
1.H.3.2.7









Tos7p of 515 aas and 4 N-terminal TMSs in a 1 + 3 TMS arrangement. Tos7 contributes to cell surface-related functions probably as an auxiliary component of the MCC/eisosome complex that  interacts with and regulates the secretory pathway (Zhu et al. 2020).

Eukaryota
Fungi, Ascomycota
Tos7 of Saccharomyces cerevisiae (baker's yeast)
1.H.3.3.1









Uncharacterized protein of 367 aas and 4 TMSs in a 1 + 3 TMS arrangement.

Eukaryota
UP of Monosiga brevicollis
1.H.3.3.2









Uncharacterized protein of 597 aas and 4 N-terminal TMSs in a 1 + 3 TMS arrangement followed by a large hydrophilic domain that shows extensive sequence similarity with 1.W.6.4.1.

Eukaryota
UP of Monosiga brevicollis
1.H.3.3.3









Uncharacterized protein of 262 aas and either 4 or 6 TMSs in a 1 + 3 or 3 + 3 TMS arrangement, respectively.

Eukaryota
UP of Salpingoeca rosetta
1.H.3.3.4









Uncharacterized protein of 179 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement.

Eukaryota
Metazoa, Nematoda
UP of Ancylostoma ceylanicum
1.H.3.3.5









Uncharacterized protein of 195 aas and 4 TMSs in a 1 + 2 + 1 TMS arrangement.

Eukaryota
Metazoa, Nematoda
UP of Steinernema carpocapsae
1.H.3.3.6









Unharacterized protein of 209 aas and 4 TMSs in a 1 + 3 TMS arrangement.

Eukaryota
Metazoa, Nematoda
UP of Caenorhabditis brenneri
1.H.3.4.1









Uncharacterized protein of 251 aas and 4 TMSs in a 1 + 3 TMS arrangement

Eukaryota
Euglenozoa
UP of Leptomonas pyrrhocoris
1.H.3.4.2









Uncharacterized protein of 227 aas and 4 or 5 TMSs in a 1 + 2 + 1 or 1 + 3 + 1 TMS arrangement.

Eukaryota
Euglenozoa
UP of Trypanosoma theileri
1.H.3.4.3









Uncharacterized protein of 221 aas and 4 TMSs in a 1 + 3 TMS arrangement.

Eukaryota
Euglenozoa
UP of Trypanosoma equiperdum