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1.I.1.1.2
Fungal Nuclear Pore Complex (NPC) with 29 components.  Stuwe et al. 2015 presented the reconstitution of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. They proposed that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation (Stuwe et al. 2015 presented the reconstitution of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. They proposed that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation (Stuwe et al. 2015).

Accession Number:G0SBS8
Protein Name:Nucleoporin NUP159
Length:1481
Molecular Weight:156196.00
Species:Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [759272]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Nucleus1
Substrate protein polypeptide chain, (ribonucleotide)n+m

Cross database links:

Structure:
5CWW     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFSFGNAGG GGGGVTQGKD LEVIQTEGLG FLALAGDAKV QLTSKWSPPP APTASLLSIA 
61:	SRKGLVAAAG PDAVHVATTE SVRKAFLAEK NGDSEVRPFN PEAKLPLPLR ISQLAFTADE 
121:	QYLVLSAETG GGLRAYDVNS LTQGNTQSAF ELATNGETLR QLAPNPMPES AAFCAIVTTN 
181:	GNLYMANLAE RTLVSGPNGP TLRSQVSCAA WSTKGKQLVA GMADGSIYQM TPDGTEKAHI 
241:	PKPPNLGDYH VSSVVWLENN VFLTIHNPTN STNPDDKTVY HVITRQQSSG SPPNFTFQKL 
301:	NDPVEPFVAD KTPHHTVLRL KDFPPNLQDL LLVSSTAVET IGLLTRSKTP LATDKPADAI 
361:	TNVFTTTELA DDSRRAQLPM SEDMMETYPI GVALDLSSKE KVYKPIPTDE EIEYSPGPLP 
421:	GLWVLNNEGV LASWWVVYNE SIRAGTTYSG IGGSSEVIPA SPAPALASST APVPAFASPV 
481:	SKPTFGSPSP ATPAFGGPSA LGTKASPWAT AGGAASSTPT FGQPSFGKPA APAFGQASFP 
541:	GLGQKVSPWA TGSTTSAAPA FGQSGFASAG TAPGKVFGSS FTAPSSGGFA SFATKSGFAS 
601:	LSAPSGGSSI FSSKPGAPLT SAAPEVSMDT DTAFPPPSTK TDKPAFGSSP FVLGSTFKAD 
661:	PTAAHDIEKP KEGESKSLFD TGFGLSLEDA AKQPASAAES KDEEMRSTTP PLPPPTETKP 
721:	KSIFESTTPT TTPAPQKFEF KTTTPSGFST LLGSTKPVAS SMPNIFATPK PTSAEKPKSI 
781:	FDTLKPKEES KENLLKASEP PLPPDTTSKA VFQPGSSSSE SAESSPGAAA KAAFKVGNDE 
841:	TPKPQKELAP KPEAVPLPPD FVKAKPKTEA KETKAEEPAV SPNLPVKPLA KKAEPIPAVP 
901:	ESASEEEQGQ AEEEEAESGE EEEEEEEEGE GEEEEEEEEE EEEEEEEGEE GEEQSEAGSE 
961:	GSGVDVAKDL SPTAKFGSMT PGYTPHTSLG GMAESTFSTI SRSEVAEQSR PLFGEITKNA 
1021:	PPLFPAAGPL PVSPRSPSPV RGVVRSSILR PTETPRPVDT TPVPSRKGLL QKTASFGMST 
1081:	GQKPAVDPNV KAQRKLAEKL KAEEQVLVDP EDEGIQQILQ SKVEPTLRMN EFLAVDTKLA 
1141:	PMKPGRDDVP NACETLWRDI NRMIDRLGLN SRSLQSFILG HTSHGKPGGR QKDDLEKPDD 
1201:	WVLIEAYDLG DMIDNKLARE LEAGRIKDVE GTMAAIHNLG RDLAKLRAKE EDLRKLFNAQ 
1261:	VDPDQIALTK ALPLSAEQLA QQNELRRSYA SFSKLLTEAE EALTVLKAKL ASANAARGRR 
1321:	GAGAAQVPTV DAIIRTINKM TSMAEKRSGD IDVLESQMRK LRIGSLGPAG TPNGNGVGAG 
1381:	TVVPATPGGG GRSRESSPFV TPQSSRRAMF MSPGSVGTAT PRGLLAATGT PSPTKKKLSM 
1441:	YTAEEKRELR AREAKRKATL RMLRESLARV GPNVVRLRDD D