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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
1.M.1.1.1	The Spanin1 (Rz; inner membrane, IM)/Spanin2 (Rz1; outer membrane, OM) complex. Spanin1, 153 aas; Spanin2, 60 aas. Together they span the periplasm and mediate fusion of the IM and OM. By doing so, they disrupt the double membrane barrier (Berry et al. 2008; Rajaure et al. 2015; Kongari et al. 2018).	Viruses	Heunggongvirae, Uroviricota	Rz/Rz1 of E. coli phage lambda
1.M.1.1.2	Rz/Rz1 spanin complex of Burkholderia phage BcepIL02	Viruses	Heunggongvirae, Uroviricota	Rz/Rz1 of Burkholderia phage BcepIL02 Rz, (171 aas; C5IHR7) Rz1 (71 aas; C5IHR8)
1.M.1.1.3	Putative Rz (143 aas; W1IXJ3) inner membrane spanin (i-spanin) of a possible Rz/Rz1 spanin complex of lambdoid prophage Rac. No o-spanin was found, but an adjacent gene (UniProt encodes a 62 aa addiction module toxin, HicA which could be either a o-spanin or a toxin which could be exported via the Rz protein.	Bacteria	Pseudomonadota	Rz protein of Xenorhabdus szentirmaii
1.M.1.1.4	Two component spanin consisting of Rz (IM, 145 aas and 1 TMS) and Rz1 (OM, 61 aas and 1 TMS).	Viruses	Heunggongvirae, Uroviricota	Spanin of Enterobacteria phage P22 (Bacteriophage P22)
1.M.1.1.5	Putative spanin of 164 aas and 1 TMS	Bacteria	Pseudomonadota	Putative spanin of Arsenophonus nasoniae (son-killer infecting Nasonia vitripennis)
1.M.1.1.6	Putative phage spanin Rz of 128 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	PPS of Mycobacterial phage Ptience, gene 45.
1.M.1.1.7	Putative phage spanin, Aminay, of 132 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	PPS of Mycobacterial phage spanin, Aminay.
1.M.1.1.8	Uncharacterized protein of 107 aas and 1 N-terminal TMS.	Bacteria	Actinomycetota	UP of Prescottella equi (Rhodococcus equi)
1.M.1.1.9	Uncharacterized protein, putative spanin, of 134 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Mycobacterium phage Rope
1.M.1.1.10	Uncharacterized protein, SEA_CAMERICO_42, of 125 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Gordonia phage Camerico
1.M.1.1.11	Uncharacterized protein of 122 aas and 1 TMS.	Bacteria	Pseudomonadota	UP of Aminobacter aminovorans
1.M.1.1.12	Uncharacterized protein of 122 aas and 1 TMS.	Bacteria	Pseudomonadota	UP of Mesorhizobium tamadayense
1.M.1.1.13	Putative phage spanin of 126 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PPS of Mesorhizobium sp.
1.M.1.2.1	Rz-like/Rz1-like spanin complex; Rz-like, 148 aas and Rz1-like, 163 aas.	Viruses	Heunggongvirae, Uroviricota	Rz/Rz1 complex of Klebsiella phage KP32
1.M.1.2.2	Two component Spanin, eRz/eRz1 of 147 and 74 aas, respectively.	Viruses	Heunggongvirae, Uroviricota	Spanin of Pseudomonas phage Phi15
1.M.1.2.3	Spanin pair: i-spanin (gene 18.5; 143 aas; P03803) + o-spanin (gene 18.7; 83 aas; P03788).	Viruses	Heunggongvirae, Uroviricota	Spanin pair of Phage T7
1.M.1.2.4	Uncharacterized protein of 162 aas and 1 N-terminal TMS.	Bacteria	Thermodesulfobacteriota	UP of Desulfovibrio sp. (coral metagenome)
1.M.1.2.5	Uncharacterized protein of 123 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of E. coli phage rB
1.M.1.3.1	Putative two component spanin (of 109 and 89 aas, each with 1 TMS).	Viruses	Heunggongvirae, Uroviricota	Spanin of Enterobacteria phage phiKMV (Pseudomonas phage phiKMV)
1.M.1.3.2	Spanin (i-spanin of 114 aas and o-spanin of 82 aas)	Viruses	Heunggongvirae, Uroviricota	Spanin of Caulobacter phage Percy
1.M.1.3.3	Uncharacterized putative spanin protein of 136 aas.	Viruses	Heunggongvirae, Uroviricota	Putative spanin of Burkholderia phage Bp-AMP1
1.M.1.3.4	Putative inner membrane i-panin of 90 aas and 1 N-terminal TMS, Rz, and putative outer membrane spanin, o-spanin of 107 aas with 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	Spanin of Ralstonia phage RSJ2
1.M.1.3.5	Putative two component spanin, Rz of 118 aas and Rz1 of 83 aas.	Viruses	Heunggongvirae, Uroviricota	Rz/Rz1 of Burkholderia phage JG068
1.M.1.3.6	Spanin Rz/Rz1 pair of 110 and 86 aas, each with 1 N-terminal TMS	Viruses	Heunggongvirae, Uroviricota	Rz/Rz1 of Caulobacter phage Cd1
1.M.1.3.7	Rz/Rz1 spanin pair of 142 and 82 aas, respectively.	Bacteria	Pseudomonadota	Rz/Rz1 of Klebsiella pneumoniae
1.M.1.3.8	Putative spanin complex with two proteins of 109 and 136 aas, both with an N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	Spanin of phage APSE-6
1.M.1.3.9	Uncharacterized spanin Rz homologue of 224 aas and 1 TMS.	Bacteria	Bacillota	UP of Butyrivibrio sp. AE3004
1.M.1.3.10	Putative spanin of 248 aas and 0 TMSs	Bacteria	Pseudomonadota	UP of Labrenzia alexandrii
1.M.1.3.11	Two component spannin, LysB (R4JGE0)/LysC (R4JDL9) of 146 and 97 aas, respectively. LysBC can lyse E. coli cells (Khakhum et al. 2016).	Viruses	Heunggongvirae, Uroviricota	LysB/LysC of Burkholderia phage ST79
1.M.1.3.12	Uncharacterized protein of 114 aas and 1 TMS.	Viruses	Bamfordvirae, Nucleocytoviricota	UP of Acanthocystis turfacea Chlorella virus TN603.4.2
1.M.1.3.13	Putative spanin (phage hypothetical protein of Tenacibaculum maritimum) of 115 aas and possibly 1 N-terminal TMS.	Bacteria	Bacteroidota	Putative spanin of Tenacibaculum maritimum
1.M.1.3.14	Spanin complex consisting of inner and outer membrane spanin (i- and o-spanin) components of 162 and 129 aas, respectively.	Viruses	Heunggongvirae, Uroviricota	Spannin of Caulobacter phage phiCbK
1.M.1.3.15	Spanin (inner membrane spanin of 168 aas and outer membrane spanin of 126 aas.	Viruses	Heunggongvirae, Uroviricota	Spanin of Caulobacter phage CorColossus
1.M.1.3.16	Putative phage spanin of 153 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PPS of Histophilus somni
1.M.1.3.17	Phage spanin of 148 aas and 1 N-terminal TMS.		Pseudomonadota	Spanin of Pseudoalteromonas distincta
1.M.1.3.18	Phage spanin Rz of 145 aas and 1 N-terminal TMS, Shewanella frigidmarina strain NCIMB 400, Gene: Sfri_1672	Bacteria	Pseudomonadota	Spanin Rz of Shewanella frigidmarina strain NCIMB 400
1.M.1.3.19	Uncharacterized phage spanin Rz of 114 aas and 1 TMS.	Viruses	Bamfordvirae, Nucleocytoviricota	Rz ofAcanthocystis turfacea Chlorella virus TN603.4.2
1.M.1.3.20	Uncharacterized protein HOR29, gp46, of 119 aas with 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Pectpbacterium phage PP2
1.M.1.3.21	Uncharacterized protein of 119 aas	Bacteria	Pseudomonadota	UP of Jiella sp. CBK1P-4
1.M.1.3.22	Uncharacterized DUF6468 domain-containing protein of 116 aa	Bacteria	Pseudomonadota	UP of Aureimonas sp. AU20
1.M.1.3.23	Phage spanin Rz of 111 aa	Bacteria	Pseudomonadota	Rz of Fulvimarina pelagi HTCC2506
1.M.1.3.24	Putative phage spanin of 94 aas and 1 TMS from a Xylella phage.	Viruses	Heunggongvirae, Uroviricota	PPS of a Xylella phage
1.M.1.3.25	Putative spanin of 124 aas and 1 or 2 TMSs, where the N-terminal TMS is strongly hydrophobic while the secon putative TMS is only moderately hydrophobic.	Viruses	Heunggongvirae, Uroviricota	Putative Rz spanin of Croceibacter phage P2559S
1.M.1.3.26	Uncharacterized putative spanin of 107 aas and 2 TMSs, N- and C-terminal.	Bacteria	Bacteroidota	UP of Chryseobacterium carnipullorum
1.M.1.3.27	o-Spanin of 73 aas and 1 N-terminal TMS	Bacteria	Campylobacterota	o-Spanin of Helicobacter acinonychis strain Sheeba, prophage II, orf25.
1.M.1.3.28	Uncharacterized protein of 84 aas and 1 TMS.	Bacteria	Campylobacterota	UP of Helicobacter suis
1.M.1.3.29	Uncharacterized protein of 120 aas and 1 TMS.	Bacteria	Campylobacterota	UP of Helicobacter suis
1.M.1.3.30	Putative phage spanin of 210 aas with 1 N-terminal TMS.	Bacteria	Bacteroidota	Pps of Fibrella aestuarina
1.M.1.3.31	Putative phage i-spainin of 205 aas and 1 N-terminal TMS.	Bacteria	Bacteroidota	PPS of Spirosoma terrae
1.M.1.3.32	Uncharacterized protein of 192 aas and 1 TMS.	Bacteria	Bacteroidota	UP of Spirosoma sp. KCTC 72228
1.M.1.3.33	Uncharacterized protein of 121 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Cronobacter phage vB_CskP
1.M.1.3.34	Putative lipoprotein of 79 aas with one N-terminal TMS. It may be a bacterial lysin (Liu et al. 2023).	Bacteria	Campylobacterota	LP of Campylobacter hyointestinalis subsp. hyointestinalis
1.M.1.4.2	Uncharacterized Rz spanin of 180 aas and 1 TMS.	Bacteria	Pseudomonadota	Rz of Ralstonia solanacearum
1.M.1.4.3	Lysis system i-spanin subunit Rz of 166 aas	Bacteria	Pseudomonadota	UP of Microvirgula aerodenitrificans
1.M.1.4.4	Annotated as "lysozyme" of 208 aas and 1 N-terminal TMS. A member of the Pfam Phage_lysis superfamily. However, it appears to be a large spanin and is designated here as an uncharacterized protein (UP) (unpublished observations).	Bacteria	Pseudomonadota	UP of Pseudomonas fluorescens
1.M.1.4.5	Probable spanin of 165 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	Spanin of Luteibacter sp.
1.M.1.4.6	Putative i-spanin of 172 aas with 1 N-terminal TMS. It is from Escherichia phage ECML-117 (UniProt acc # I7ATQ8).	Viruses	Heunggongvirae, Uroviricota	Spanin of Escherichia phage ECML-117
1.M.1.4.7	Phage spanin of 165 aas and 1 N-terminal TMS.	Viruses	Duplodnaviria	PS of Myoviridae sp. (insect metagenome)
1.M.1.4.8	Uncharacterized protein of 177 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	UP of Sphaerotilus montanus
1.M.1.4.9	Putative phage spanin Rz of Sideroxydans lithotrophicus (strain ES-1) of 171 aas and 1 N-terminal TMS (Uni Prot acc # D5CTS4).	Bacteria	Pseudomonadota	PPS12 of Sideroxydans lithotrophicus (strain ES-1)
1.M.1.4.10	Uncharacterized spanin of 227 aas and 0 TMSs	Bacteria	Pseudomonadota	UP of Pseudomonas sp. StFLB209
1.M.1.4.11	Phage-like spanin of 166 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PS of Albitalea terrae
1.M.1.4.12	Uncharacterized protein of 184 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	UP of Vibrio vulnificus
1.M.1.4.13	Rz/RzI spanin protein of 166 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	Rz/RzI of Escherichia phage IME11
1.M.1.4.14	Uncharacterized protein, i-spanin 114 of 114 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	i-spanin 114 of Stutzerimonas stutzeri
1.M.1.4.15	i-spanin 114 of 114 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	Putative phage spanin of Stutzerimonas stutzeri
1.M.1.4.16	Uncharacterized protein of 131 aas and 1 TMS.	Bacteria	Pseudomonadota	UP of Rhizobium leguminosarum
1.M.1.4.17	Uncharacterized protein of 108 aas and 1 N-terminal TMS.	Bacteria	Proteobacteria	UP of Methyloterrigena soli
1.M.1.4.18	Uncharacterized protein annotated as a P-loop NTPase superfamily protein of 131 aas and 1 TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Dinoroseobacter phage vB_DshS-R5C
1.M.1.4.19	Uncharacterized protein of 113 aas.	Viruses	Duplodnaviria	UP of Myoviridae
1.M.1.4.20	Putative phage spanin of 138 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	PPS of Pseudomonas phage PAK P5 (Gene: PAK_P500031)
1.M.1.4.21	Uncharacterized protein of 123 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Cronobacter phage CR3
1.M.1.4.22	Uncharacterized protein of 134 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Cronobacter phage vB_CsaM_GAP31
1.M.1.4.23	Uncharacterized protein of 161 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Pseudomonas phage PhiH2
1.M.1.4.24	Putative spanin of Pseudomonas phage KPP23, gene 008.	Viruses	Heunggongvirae, Uroviricota	Putative spanin of Pseudomonas phage KPP23
1.M.1.4.25	Putative phage spanin of 125 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PPS of Stenotrophomonas maltophilia
1.M.1.4.26	Putative phage spanin of 134 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PPS of Neisseria meningitidis serogroup B (strain MC58)
1.M.1.4.27	Uncharacterized protein of 217 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	UP of Yersinia massiliensis
1.M.1.4.28	Uncharacterized putative phage spanin Rz of Klebsiella pneumoniae of 211 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	Putative spanin of Klebsiella pneumoniae
1.M.1.4.29	Putative phage spanin of 133 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PPS of Mesorhizobium sp. L103C120A0
1.M.1.4.30	Putative phage spanin of 156 aas and 1 N-terminal TMS.	Bacteria	Pseudomonadota	PPS of Oricola thermophila
1.M.1.4.31	Putative phage spanin of 120 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	PPS of Aeromonas phage CC2
1.M.1.4.32	Uncharacterized protein of 128 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	UP of Aeromonas phage Ah1
1.M.1.4.33	Uncharacterized putative i-spanin protein of 98 aas.	Viruses	Heunggongvirae, Uroviricota	UP of Vibrio phage VBM1
1.M.1.4.34	i-Spanin of 163 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	i-Spanin of Vibrio phage SSP002
1.M.1.5.1	Outer membrane lipoprotein o-spanin/inner membrane i-spanin complex, pseT.2/pseT.3 (Summer et al. 2007).	Viruses	Heunggongvirae, Uroviricota	PseT.2/PseT.3 of enterobacterial phage T4 PseT.2 of 99 aas PseT.3 of 117 aas
1.M.1.5.2	i-spanin/o-spanin of 115/95 aas, respectively, each with an N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	Spanin of Seratia phage SP1
1.M.1.5.3	i-Spanin/o-spanin of 110 aas/116 aas, respectively, both with one N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	Spanin of Enterobacter phage ENC9
1.M.1.5.4	Putative phage R1 spanin protein of 120 aas and 1 N-terminal TMS.	Viruses	Heunggongvirae, Uroviricota	PPS of Pectobacterium phage Arno160
1.M.1.5.5	Putative phage i-spanin of 149 aas and 1 N-terminal TMS (Orf046).	Viruses	Heunggongvirae, Uroviricota	PPS of Escherichia phage vB EcoS AKFV33