1.N.3.1.3
Male gamete fusion factor, HAP-2 of 742 aas and at least 2 TMSs. HAP2 is expressed in all seven mating types of T. thermophila and
fertility is only blocked when the gene is deleted from both cells of a
mating pair. HAP2 deletion strains of complementary mating types can
recognize one another and form pairs, but pair stability is
compromised and membrane pore formation at the nuclear exchange junction
is blocked (Cole et al. 2014). Cole et al. 2014 proposed a model in which each of the several hundred membrane pores
established at the conjugation junction of mating Tetrahymena represents
the equivalent of a male/female interface, and that pore formation is
driven on both sides of the junction by the presence of HAP2.
|
| Accession Number: | Q22C76 |
|---|
| Protein Name: | Male gamete fusion factor |
|---|
| Length: | 742 |
|---|
| Molecular Weight: | 82663.00 |
|---|
| Species: | Tetrahymena thermophila (strain SB210) [312017] |
|---|
| Number of TMSs: | 2 |
|---|
| Substrate |
molecule, macromolecule |
|---|
1: MKFLAFGLIY FHFCILNRCE YITSSTIQKC YNSSNEPNNC SQKAVIVLSL ENGQIANTEQ
61: VVATLNQLSD SGVNKQLQNS FIFEVTKSPV TALFPLIYLQ DFNSQPLEQV IATTLFSCKD
121: GFYDSSPTCK FQYDSKGQKI LDSQGYCCYC SLSDILGMGN DLSRGKVCYA LNLGAGSATA
181: HCLKFSPLWY SAFKIQQYQL YFEVNINIYT VDSQNQKNLK QTLKLSTSNP TMKSSDNSTI
241: SKIIGTFTPT QPPADLSSYY LVKPSFPATD PRVLQGISSW MFVDKTMFTL DGTQCNKIGV
301: SYSGFRQQSS SCSQPVGSCL QNQLENLYQS DLILLSQNKQ PKYLLESQGN FNQVQFQGQT
361: ILQQGLSGSA STLITIEIDA AQIKFVTNLG IGCISQCSIN NFESHSGNGK LVALVQNQGN
421: YSAEFVLGFN CSSNVQPIQG QKLFLTANQL YNFNCSVSVN SDISAINNNC TINLYDAIGN
481: QLDSKNILFN TTSTNHTSNQ GNNTGQQQSS QEYKSSQSCS DKCSSFWSFW CYFSAGCIKE
541: AFKSIASIAG VASALALVIF LAKNGYLVPI IRFLCCCCCK SKKKENEKNK DKTDKKSIQE
601: SCSYDRSCCS HSISQSYQVE NKNKYKRSKI QRSFSSESCQ DKSKKIINEL SNLEETFEAN
661: KLYANIDKNS SIFEYFGFKK SFTFILYERN DILFLPQNST ILDMIGALQP QKGSYLAQKF
721: LEIVNKNALK VVSTSPLYLL IE