1.N.5.1.2
Atlastin of 541 aas and 2 TMSs near the C-terminus of the protein. It is a GTPase, tethering membranes through
formation of trans-homooligomers and mediating homotypic fusion of
endoplasmic reticulum membranes (Orso et al. 2009). It functions in endoplasmic reticulum
tubular network biogenesis and may also regulate microtubule polymerization
and Golgi biogenesis. It is required for dopaminergic neurons survival and
the growth of muscles and synapses at neuromuscular junctions (Lee et al. 2009).
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| Accession Number: | Q9VC57 |
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| Protein Name: | Atlastin |
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| Length: | 541 |
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| Molecular Weight: | 60912.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGGSAVQVIN ASEEHTFVLN EDALSEVLMR DEVKDRFVCV VSVAGAFRKG KSFLLDFFLR
61: YMYSKYVHHD ATDWLGGESD PLEGFSWRGG SERDTTGILM WSDIFLHDYP NGDKIAIILL
121: DTQGAFDSQS TVRDCATVFA LSTMLSSVQI YNLSQNIQED DLQHLQLFTE YGRLALADTG
181: KKPFQRLQFL VRDWSFPYEA EYGALGGDKI LKRRLEVSDK QHPELQSLRR HISSCFTEVA
241: CFLMPHPGLN VATNPKFDGR LQDITPEFKS SLRSLVPMLL APDNLVYKEI SGQRVRARDL
301: IQYFQSYMNI YKGNELPEPK SMLVATAEAN HLTAVAAAKE LYGQLMEEVC GGTRPYLSTA
361: HLQTEHLRVK DKALFQFAAK RKMGGEEFTE KFRKQLEDDL EEVFTNYQAH NESKNIFKAA
421: RTPAVYFACA VIMYILSGIF GLVGLYTFAN FCNLVMGVAL LTLALWAYIR YSGELSDFGG
481: KLDDFATLLW EKFMRPIYHG CMEKGIHHVA THATEMAVGG GAASYRSQTS VNASNGKVKR
541: S