1.R.2.1.1
The BLTP3B protein of 1464 aas and 0 - 2 TMSs. Also called the SHIP164 protein. BLTP3B or SHIP164 is of 1464 aas and 0 - 2 TMSs. It is a tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites and is required for retrograde trafficing of vesicle clusters in the early endocytic pathway to the Golgi complex (Otto et al. 2010). Cellular membranes differ in protein and lipid compositions as well as in
the protein-lipid ratio. Progression of membranous organelles
along traffic routes requires mechanisms to control bilayer lipid
chemistry and their abundance relative to proteins. Structural and functional characterization of VPS13-family proteins has
suggested a mechanism through which lipids can be transferred in bulk
from one membrane to another at membrane contact sites, and thus
independently of vesicular traffic. Hanna et al. 2022 showed that SHIP164
(UHRF1BP1L) shares structural and lipid transfer properties with these
proteins and is localized on a subpopulation of vesicle clusters in the
early endocytic pathway whose membrane cargo includes the
cation-independent mannose- 6-phosphate receptor (MPR). Loss of SHIP164
disrupts retrograde traffic of these organelles to the Golgi complex.
These findings raise the possibility that bulk transfer of lipids to
endocytic membranes may play a role in their traffic (Hanna et al. 2022).
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| Accession Number: | A0JNW5 |
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| Protein Name: | Bridge-like lipid transfer protein family member 3B |
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| Length: | 1464 |
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| Molecular Weight: | 164199.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
lipid |
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1: MAGIIKKQIL KHLSRFTKNL SPDKINLSTL KGEGELKNLE LDEEVLQNML DLPTWLAINK
61: VFCNKASIRI PWTKLKTHPI CLSLDKVIME MSTCEEPRSP NGPSPIATAS GQSEYGFAEK
121: VVEGISVSVN SIVIRIGAKA FNASFELSQL RIYSVNAHWE HGDLRFTRIQ DPQRGEVLTF
181: KEINWQMIRI EADATQSSHL EIMCAPVRLI TNQSKIRVTL KRRLKDCNVI ATKLVLILDD
241: LLWVLTDSQL KAMVQYAKSL SEAIEKSTEQ RKSMAPEPTQ SSTVVASAQQ VKTTQTSNAP
301: DVNDAIVKLF NDFDVKETSH HLVISHLDLH ICDDIHAKEK ESNRRITGGA MQLSFTQLTI
361: DYYPYHKAGD SCNHWMYFSD ATKTKNGWAN ELLHEFECNV EMLKQAVKDH NVGSPPKSPT
421: HASPQHTQTE KDYPLKGTCR TPSVLSQQSK AKLMSSSVVV RLADFNIYQV STAEQCRSSP
481: KSMICCNKKS LYLPQEMSAV YIEFTEYYYP DGKDFPIPSP NLYSQLNALQ FTVDERSILW
541: LNQFLLDLKQ SLNQFMAVYK LNDNSKSDEH VDVRVDGLML KFVIPSEVKS ECHQDQPRAI
601: SIQSSEMIAT NTRHCPNCRH SDLEALFQDF KDCDFFSKTY TSFPKSCDNF NLLHPIFQRH
661: AHEQDTKMHE IYKGNITPQL NKNTLKTSAA TDVWAVYFSQ FWIDYEGMKS GKGRPISFVD
721: SFPLSIWICQ PTRYAESQKE PQTCNQVSLN TSQSESSDLA GRLKRKKLLK EYYSTESEPL
781: TNGGQKPSSS DTFFRFSPSS SEADIHLLVH VHKHVSMQIN HYQYLLLLFL HESLILLSEN
841: LRKDVEAVTG SPASQTSICI GILLRSAELA LLLHPVDQAN TLKSPVSESV SPVVPDYLPT
901: ENGDFLSSKR KQISRDINRI RSVTVNHMSD NRSMSVDLSH IPLKDPLLFK SASDTNLQKG
961: ISFMDYLSDK HLGKISEDES SGLVYKSGSG EIGSETSDKK DSFYTDSSSI LNYREDSNIL
1021: SFDSDGNQNI LSSTLTSKGN ETIESIFKAE DLLPEAASLS ENLDISKEET PPVRTLKSQS
1081: SLSGKPKERC PPNLAPLCVS YKNMKRSSSQ MSLDTISLDS MILEEQLLES DGSDSHMFLE
1141: KGNKKNSTTN YRGTAESVNA GANLQNYGET SPDAISTNSE GAQENHDDLM SVVVFKITGV
1201: NGEIDIRGED TEICLQVNQV TPDQLGNISL RHYLCNRPVG SDQKAVIHSK SSPEISLRFE
1261: SGPGAVIHSL LAEKNGFLQC HIENFSTEFL TSSLMNIQHF LEDETVATVM PMKIQVSNTK
1321: INLKDDSPRS STVSLEPAPV TVHIDHLVVE RSDDGSFHIR DSHMLNTGND LKENVKSDSV
1381: LLTSGKYDLK KQRSVTQATQ TSPGVPWPSQ SANFPEFSFD FTREQLMEEN ESLKQELAKA
1441: KMALAEAHLE KDALLHHIKK MTVE