2.A.1.1.129
High-capacity facilitative transporter for
trehalose, TRET1, required to induce anhydrobiosis. Anhydrobiotic larvae can
survive almost complete dehydration. Does not transport maltose, sucrose
or lactose. Transports trehalose synthesized in the fat body
and incorporates trehalose into other tissues that require a
carbon source, thereby regulating trehalose levels in the hemolymph (Kikawada et al. 2007; Kanamori et al. 2010). 70% identical to the Drosophila homologue, TC# 2.a.1.1.99.
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| Accession Number: | A5LGM7 |
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| Protein Name: | Facilitated trehalose transporter Tret1 |
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| Length: | 504 |
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| Molecular Weight: | 55057.00 |
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| Species: | Polypedilum vanderplanki (Sleeping chironomid) [319348] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
alpha,alpha-trehalose |
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1: MELNNKEDSP RHTVPFVRQI TEDGKAKLEI YRPTTNPIYI YTQILAAIAV SMGSMVVGFA
61: SAYTSPALVS MQNTTITSFK VTEQEASWVG GIMPLAGLAG GIAGGPFIEY LGRKNTILAT
121: AVPFIVAWLL IAFANSIWMV LAGRALSGFC VGIASLSLPV YLGETVQPEV RGTLGLLPTA
181: FGNIGILICF VAGKYVNWSG LAFIGSILPI PFMVLTLLIP ETPRWFVTRG REERARKALQ
241: WLRGKKADVE PELKGIVKSH CEAERHASQN AIFDLMKRSN LKPLLIALGL MFFQQLSGIN
301: AVIFYTVSIF KDAGSTIDEN LCTIIVGVVN FGATFFATVL IDRLGRKILL YISEVAMVIT
361: LLTLGTFFYY KNSGNDVSNI GWLPLASFVI YVIGFSSGVG PIPWLMLGEI LPGKIRGSAA
421: SVATGFNWTC TFIVTKTFAD IVAAIGNHGA FWFFGVICLI GLFFVIFFVP ETQGKSLEEI
481: ERKMMGRVRR MSSVANMKPL SFNM