TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.1.24
Hexose (Glucose and Fructose) transporter, PfHT1 of 504 aas and 12 TMSs. This is the only hexose transporter, and it is found in the plasma membrane. It is an antimalarial drug target (Meier et al. 2018).

Accession Number:O97467
Protein Name:PfHT1 aka HT1 aka PFB0210C
Length:504
Molecular Weight:56417.00
Species:Plasmodium falciparum [5833]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Hexoses

Cross database links:

Pfam: PF00083   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter.”  Woodrow C.J.et.al.   10066789
Structure:
6M20   6M2L   6RW3     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MTKSSKDICS ENEGKKNGKS GFFSTSFKYV LSACIASFIF GYQVSVLNTI KNFIVVEFEW 
61:	CKGEKDRLNC SNNTIQSSFL LASVFIGAVL GCGFSGYLVQ FGRRLSLLII YNFFFLVSIL 
121:	TSITHHFHTI LFARLLSGFG IGLVTVSVPM YISEMTHKDK KGAYGVMHQL FITFGIFVAV 
181:	MLGLAMGEGP KADSTEPLTS FAKLWWRLMF LFPSVISLIG ILALVVFFKE ETPYFLFEKG 
241:	RIEESKNILK KIYETDNVDE PLNAIKEAVE QNESAKKNSL SLLSALKIPS YRYVIILGCL 
301:	LSGLQQFTGI NVLVSNSNEL YKEFLDSHLI TILSVVMTAV NFLMTFPAIY IVEKLGRKTL 
361:	LLWGCVGVLV AYLPTAIANE INRNSNFVKI LSIVATFVMI ISFAVSYGPV LWIYLHEMFP 
421:	SEIKDSAASL ASLVNWVCAI IVVFPSDIII KKSPSILFIV FSVMSILTFF FIFFFIKETK 
481:	GGEIGTSPYI TMEERQKHMT KSVV