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2.A.1.1.4 Glucose uniporter of 473 aas and 12 TMSs. Several GLUT isoforms, especially GLUT1 and GLUT3 in humans, are overexpressed in many tumors, and inhibitors have been identified (Kawatani and Osada 2025).
Accession Number:	P21906
Protein Name:	Glf
Length:	473
Molecular Weight:	50115.00
Species:	Zymomonas mobilis [542]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	glucose

RefSeq:	YP_162101.1
Entrez Gene ID:	3188586
Pfam:	PF00083
BioCyc:	ZMOB264203:ZMO0366-MONOMER
KEGG:	zmo:ZMO0366
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0022891 F:substrate-specific transmembrane transporte... GO:0008643 P:carbohydrate transport GO:0055085 P:transmembrane transport
References (2) [1] “Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism.” Barnell W.O.et.al. 2254282 [2] “The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4.” Seo J.-S.et.al. 15592456

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSSESSQGLV TRLALIAAIG GLLFGYDSAV IAAIGTPVDI HFIAPRHLSA TAAASLSGMV 
61:	VVAVLVGCVT GSLLSGWIGI RFGRRGGLLM SSICFVAAGF GAALTEKLFG TGGSALQIFC 
121:	FFRFLAGLGI GVVSTLTPTY IAEIAPPDKR GQMVSGQQMA IVTGALTGYI FTWLLAHFGS 
181:	IDWVNASGWC WSPASEGLIG IAFLLLLLTA PDTPHWLVMK GRHSEASKIL ARLEPQADPN 
241:	LTIQKIKAGF DKAMDKSSAG LFAFGITVVF AGVSVAAFQQ LVGINAVLYY APQMFQNLGF 
301:	GADTALLQTI SIGVVNFIFT MIASRVVDRF GRKPLLIWGA LGMAAMMAVL GCCFWFKVGG 
361:	VLPLASVLLY IAVFGMSWGP VCWVVLSEMF PSSIKGAAMP IAVTGQWLAN ILVNFLFKVA 
421:	DGSPALNQTF NHGFSYLVFA ALSILGGLIV ARFVPETKGR SLDEIEEMWR SQK

2.A.1.1.4
Glucose uniporter of 473 aas and 12 TMSs. Several GLUT isoforms, especially GLUT1 and GLUT3 in humans, are overexpressed in many tumors, and inhibitors have been identified (Kawatani and Osada 2025).

Cross database links:

Gene Ontology

References (2)

External Searches:

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2.A.1.1.4Glucose uniporter of 473 aas and 12 TMSs. Several GLUT isoforms, especially GLUT1 and GLUT3 in humans, are overexpressed in many tumors, and inhibitors have been identified (Kawatani and Osada 2025).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.1.1.4
Glucose uniporter of 473 aas and 12 TMSs. Several GLUT isoforms, especially GLUT1 and GLUT3 in humans, are overexpressed in many tumors, and inhibitors have been identified (Kawatani and Osada 2025).