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| Accession Number: | Q9JIF3 |
| Protein Name: | Solute carrier family 2, facilitated glucose transporter member 8 aka Glut8 |
| Length: | 477 |
| Molecular Weight: | 51524.00 |
| Species: | Mus musculus (Mouse) [10090] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | glucose |
Cross database links:
| RefSeq: | NP_062361.1 |
|---|---|
| Entrez Gene ID: | 56017 |
| Pfam: | PF00083 |
| KEGG: | mmu:56017 |
Gene Ontology
GO:0030659
C:cytoplasmic vesicle membrane
GO:0005887
C:integral to plasma membrane
GO:0005536
F:glucose binding
GO:0005355
F:glucose transmembrane transporter activity
GO:0006006
P:glucose metabolic process
GO:0015758
P:glucose transport
GO:0008286
P:insulin receptor signaling pathway
GO:0001666
P:response to hypoxia
GO:0055085
P:transmembrane transport
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References (5)[1] “GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues.” Ibberson M.R.et.al. 10671487 [2] “GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity.” Doege H.et.al. 10821868 [3] “GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst.” Carayannopoulos M.O.et.al. 10860996 [4] “Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose.” Scheepers A.et.al. 11689004 [5] “Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.” Schmidt U.et.al. 16723738
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSPEDPQETQ PLLRPPEART PRGRRVFLAS FAAALGPLSF GFALGYSSPA IPSLRRTAPP 61: ALRLGDNAAS WFGAVVTLGA AAGGILGGWL LDRSGRKLSL LLCTVPFVTG FAVITAARDV 121: WMLLGGRLLT GLACGVASLV APVYISEIAY PAVRGLLGSC VQLMVVTGIL LAYVAGWVLE 181: WRWLAVLGCV PPTLMLLLMC YMPETPRFLL TQHQYQEAMA ALRFLWGSEE GWEEPPVGAE 241: HQGFQLALLR RPGIYKPLII GISLMVFQQL SGVNAIMFYA NSIFEEAKFK DSSLASVTVG 301: IIQVLFTAVA ALIMDRAGRR LLLALSGVIM VFSMSAFGTY FKLTQSLPSN SSHVGLVPIA 361: AEPVDVQVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI FPLHVKGVAT GICVLTNWFM 421: AFLVTKEFSS VMEMLRPYGA FWLTAAFCAL SVLFTLTVVP ETKGRTLEQV TAHFEGR