2.A.1.1.83
The cellobiose/cellotriose/cellodextrin/lactose transporter, Cdt-2, of 525 aas and 12 TMSs. It functions by facilitated diffusion but with low efficiency and high affinity (Km = 3 μM). Mutations can increase its activity substantially (Lian et al. 2014). It appears to be capable of catalyzing efflux of 2'-fucosyllactose (2'FL), the most abundant oligosaccharide in human breast milk, following genetic engineering (Hollands et al. 2019). It may also take up lactose (Tamayo et al. 2024).
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| Accession Number: | Q7SD12 |
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| Protein Name: | Putative uncharacterized protein |
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| Length: | 525 |
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| Molecular Weight: | 58776.00 |
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| Species: | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [367110] |
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| Number of TMSs: | 12 |
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| Substrate |
cellobiose, alpha-lactose, cellodextrin |
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1: MGIFNKKPVA QAVDLNQIQE EAPQFERVDW KKDPGLRKLY FYAFILCIAS ATTGYDGMFF
61: NSVQNFETWI KYFGDPRGSE LGLLGALYQI GSIGSIPFVP LLTDNFGRKT PIIIGCVIMI
121: VGAVLQATAK NLDTFMGGRT MLGFGNSLAQ IASPMLLTEL AHPQHRARLT TIYNCLWNVG
181: ALVVSWLAFG TNYINNDWSW RIPALLQAFP SIIQLLGIWW VPESPRFLIA KDKHDEALHI
241: LAKYHANGDP NHPTVQFEFR EIKETIRLEM ESTKNSSYLD FFKSRGNRYR LAILLSLGFF
301: SQWSGNAIIS NYSSKLYETA GVTDSTAKLG LSAGQTGLAL IVSVTMALLV DKLGRRLAFL
361: ASTGGMCGTF VIWTLTAGLY GEHRLKGADK AMIFFIWVFG IFYSLAWSGL LVGYAIEILP
421: YRLRGKGLMV MNMSVQCALT LNTYANPVAF DYFGPDHSWK LYLIYTCWIA AEFVFVFFMY
481: VETKGPTLEE LAKVIDGDEA DVAHIDIHQV EKEVEIHEHE GKSVA