2.A.1.11.11
PfMFSDT (PF3D7_0210300) is a drug exporter (Maurya et al. 2024). It confers resistance to antifungal agents, ketoconazole and itraconazole. The
nanomolar inhibitory effects of the drugs on the intra-erythrocytic
growth of Plasmodium falciparum highlight their antimalarial properties. An assay to identify inhibitors of multiple validated and potential antimalarial drug targets has been developed (Lindblom et al. 2024).
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| Accession Number: | XP_001349611.1 |
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| Protein Name: | XP_001349611.1 monocarboxylate transporter, putative [Plasmodium falciparum 3D7] |
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| Length: | 458 |
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| Molecular Weight: | |
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| Species: | Plasmodium falciparum 3D7 [36329] |
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| Number of TMSs: | 12 |
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| Substrate |
ketoconazole, botanical anti-fungal agent, itraconazole |
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1: MKKENTSLLS SRYRIILGGF LIHCTLGSIY CFSNISVYVI SYMKIIGCSD VKYKDSSWIY
61: VLTLLFQCFF GFFGGILNQN LGPQISVLLG GWLMCLGILL SYFTVFNFYL FLMTYGILCG
121: IGCGIAYPIP LSVAVKKHYD YKGVISGIIF IGRGLSVFII CPLQNYYINK YNYMPDYMPE
181: IENSDEKYFS NLDILNKVPY LFIYEGICFA IIQFLGSYLI ADSGDTSKDF MAYNDRNNKV
241: LYFEEKNFIN KPNGLSNSLR TLSNTSNFSF REVNNTFINR EFILIWLMIF FNWQAISYTQ
301: VFWKIFGMNY LSIDDRSLSL LGSVSSLFNI FGRIFWGLIS DFTSFKTTLI LMSLLMSFLT
361: ITLTMSGFYG IITYSIWVCL IFFCHAGTFA IFPSITAHTF GTKNFGPVFG LLFTARAFSS
421: IINAIISAVL LNNIGNIAMC AIVSLSSFVS IMLALAF