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2.A.1.12.2 The lactate/pyruvate:H⁺ symporter of 616 aas and 12 TMSs. Residues in the substrate translocation pathway have been reported (Soares-Silva et al., 2011). This systems and its orthologs in fungi have been reviewed (Guo et al. 2018).
Accession Number:	P36035
Protein Name:	Jen1 aka YKL217w
Length:	616
Molecular Weight:	69376.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	hydron, lactate, pyruvate

DIP:	DIP-8064N
RefSeq:	NP_012705.1
Entrez Gene ID:	853663
Pfam:	PF00083
KEGG:	sce:YKL217W
Gene Ontology GO:0016021 C:integral to membrane GO:0005739 C:mitochondrion GO:0005886 C:plasma membrane GO:0015144 F:carbohydrate transmembrane transporter acti... GO:0015129 F:lactate transmembrane transporter activity GO:0015727 P:lactate transport
References (5) [1] “The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein.” Tzermia M.et.al. 7941750 [2] “Complete DNA sequence of yeast chromosome XI.” Dujon B.et.al. 8196765 [3] “A proteomics approach to understanding protein ubiquitination.” Peng J.et.al. 12872131 [4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258 [5] “Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.” Reinders J.et.al. 17761666

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FASTA formatted sequence

1:	MSSSITDEKI SGEQQQPAGR KLYYNTSTFA EPPLVDGEGN PINYEPEVYN PDHEKLYHNP 
61:	SLPAQSIQDT RDDELLERVY SQDQGVEYEE DEEDKPNLSA ASIKSYALTR FTSLLHIHEF 
121:	SWENVNPIPE LRKMTWQNWN YFFMGYFAWL SAAWAFFCVS VSVAPLAELY DRPTKDITWG 
181:	LGLVLFVRSA GAVIFGLWTD KSSRKWPYIT CLFLFVIAQL CTPWCDTYEK FLGVRWITGI 
241:	AMGGIYGCAS ATAIEDAPVK ARSFLSGLFF SAYAMGFIFA IIFYRAFGYF RDDGWKILFW 
301:	FSIFLPILLI FWRLLWPETK YFTKVLKARK LILSDAVKAN GGEPLPKANF KQKMVSMKRT 
361:	VQKYWLLFAY LVVLLVGPNY LTHASQDLLP TMLRAQLGLS KDAVTVIVVV TNIGAICGGM 
421:	IFGQFMEVTG RRLGLLIACT MGGCFTYPAF MLRSEKAILG AGFMLYFCVF GVWGILPIHL 
481:	AELAPADARA LVAGLSYQLG NLASAAASTI ETQLADRYPL ERDASGAVIK EDYAKVMAIL 
541:	TGSVFIFTFA CVFVGHEKFH RDLSSPVMKK YINQVEEYEA DGLSISDIVE QKTECASVKM 
601:	IDSNVSKTYE EHIETV

2.A.1.12.2
The lactate/pyruvate:H⁺ symporter of 616 aas and 12 TMSs. Residues in the substrate translocation pathway have been reported (Soares-Silva et al., 2011). This systems and its orthologs in fungi have been reviewed (Guo et al. 2018).

Cross database links:

Gene Ontology

References (5)

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2.A.1.12.2The lactate/pyruvate:H+ symporter of 616 aas and 12 TMSs. Residues in the substrate translocation pathway have been reported (Soares-Silva et al., 2011). This systems and its orthologs in fungi have been reviewed (Guo et al. 2018).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.1.12.2
The lactate/pyruvate:H⁺ symporter of 616 aas and 12 TMSs. Residues in the substrate translocation pathway have been reported (Soares-Silva et al., 2011). This systems and its orthologs in fungi have been reviewed (Guo et al. 2018).