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2.A.1.12.4
Jen1 of 541 aas and 12 TMSs. Zt is a monocarboxylate (lactate) uptake porter that is upregulated following the phagocytosis of Candida albicans cells by neutrophils and macrophages. It may be important for virulence (Soares-Silva et al. 2013; Vieira et al. 2010). It may be the only lactate uptake porter and is subject to glucose catabolite repression. However, growth on lactate affects biofilm formation, morphology and susceptibility to fluconazole, and both Jen1 and Jen2 may play a role in these processes. Thus, the adaptation of Candida cells to the carbon source present in the host niches affects their pathogenicity (Alves et al. 2017; Alves et al. 2020).

Accession Number:AOW28664.1
Protein Name:AOW28664.1 Jen1p [Candida albicans SC5314]
Length:542
Molecular Weight:
Species:Candida albicans SC5314 [237561]
Number of TMSs:11
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEKARADHI SITNSNELNY DDYSNSYKNQ PELDDELFNE KPDLSLSSIS RYFATRLTTL 
61:	LDLPLYHTHK KWYEVINPIP GLKSMSKSDW NFYCLGFFAW ALDAMDFFCV SVAAPEIANT 
121:	LNISVTDVTW GVTLVLMLRS VGAVIFGIAS DYFGRKWTYI SIVTLFVVVE VGTGFVQTYQ 
181:	QFLGVRAIFG ILMGAMYPIA MVTALEGQPI AARSVLSGLF LPGYCFGYIM AMVWYRAFAG 
241:	TYKEGEGWRS LIWFSGGLSL ILIVWRLFTP ESPDYIKMKI KKEKFNQQQR LKEQEQNGGV 
301:	AVKEKKFWQK IDKSILVTFK TEWLIFSYLV LLYAGWNFTT HGSQDLYVTM ITKQYHVGLD 
361:	KKTVIIVVSN IGGIIGGIIM GQASELLGRR LTVVISIVCA GAFLYPSFFN PDRNWPAYIF 
421:	LNAFVFGSFS VGPAYLLELV NSTHRTLLSG VAYQLGNLVS SASATIEAKI GERFPLKDQP 
481:	GMFDYGKVMC IFCGAIFAYM IFIIFLGPER FHRDLQIHDT DEIEELQQDS SSNNESVKER 
541:	V