2.A.1.13.2
The low affinity aromatic amino acid (Tyr, Trp, Phe) transporter, TAT1 (T-type amino acid transporter), MCT10, Slc16a10.  Also transports N-methyl amino acids and thyroid hormones.  Essential for aromatic amino acid homeostasis in various tissues of mice (Mariotta et al. 2012). MCT10 is 58% identical to MCT8. Both transporters mediate T3 transport, but while MCT8 also transports rT3 and T4, these compounds are not efficiently transported by MCT10.  A few amino acyl residue substitutions in the human orthologue broadens the substrate specificity of this porter (Johannes et al. 2016). The Six1 trahscription factor promotes a skeletal muscle thyroid hormone response through regulation of the MCT10 transporter (Girgis et al. 2021).

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