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2.A.1.13.8
Monocarboxylate transporter, MCT10. Transports thyroid horomones as well as aromatic amino acids (Visser et al., 2010). Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011).  Deafness and loss of cochlear hair cells occurs in the absence of thyroid hormone transporters, Slc16a2 (Mct8) and Slc16a10 (Mct10) (Sharlin et al. 2018). Tissue-specific functions of thyroid hormone transporters in mice, including MCT8, MCT10 and Oatp1c1 have been reviewed (Salveridou et al. 2020).

Accession Number:Q8TF71
Protein Name:Monocarboxylate transporter 10
Length:515
Molecular Weight:55493.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate thyroid hormone

Cross database links:

Entrez Gene ID: 117247   
Pfam: PF07690   
KEGG: hsa:117247    hsa:117247   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0015801 P:aromatic amino acid transport
GO:0055085 P:transmembrane transport
GO:0006811 P:ion transport

References (10)

[1] “The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.”  Kim D.K.et.al.   11827462
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[6] “The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.”  Kim D.K.et.al.   11827462
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL AGPATAEPHE 
61:	PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE TFGSKDDDKM VFKTAWVGSL 
121:	SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA VGFVGLMSSS FVSSIEPLYL TYGIIFACGC 
181:	SFAYQPSLVI LGHYFKKRLG LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF 
241:	MFVLFLAGFT YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI 
301:	PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA DYVPGVKKVY 
361:	LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI SIMAPIAFEL VGAQDVSQAI 
421:	GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV AFYLAGVPPL IGGAVLCFIP WIHSKKQREI 
481:	SKTTGKEKME KMLENQNSLL SSSSGMFKKE SDSII