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2.A.1.19.1
The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1.  Cysteyl residues essential for transport and substrate binding have been identified (Sturm et al. 2007). Subtype-specific affinity of rat organic cation transporters rOCT1 and rOCT2 for corticosterone depends on three amino acids within the substrate binding region (Gorboulev et al. 2005). Differences in metformin and thiamine uptake between human and mouse Oct1 transporters have been demonstrated (Meyer et al. 2020).

Accession Number:Q63089
Protein Name:Oct1
Length:556
Molecular Weight:61541.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Tetramethylammonium, N'-methylnicotinamide, xenobiotics, Vitamins, Neurotransmitters

Cross database links:

RefSeq: NP_036829.1   
Entrez Gene ID: 24904   
Pfam: PF00083   
KEGG: rno:24904   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005329 F:dopamine transmembrane transporter activity
GO:0005333 F:norepinephrine transmembrane transporter ac...
GO:0015651 F:quaternary ammonium group transmembrane tra...
GO:0015872 P:dopamine transport
GO:0048241 P:epinephrine transport
GO:0015874 P:norepinephrine transport
GO:0015697 P:quaternary ammonium group transport
GO:0055085 P:transmembrane transport

References (18)

[1] “Drug excretion mediated by a new prototype of polyspecific transporter.”  Gruendemann D.et.al.   7990927
[2] “Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).”  Zhang L.et.al.   9195965
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1.”  Busch A.E.et.al.   8955087
[5] “Membrane localization of the electrogenic cation transporter rOCT1 in rat liver.”  Meyer-Wentrup F.et.al.   9703985
[6] “Catecholamine transport by the organic cation transporter type 1 (OCT1).”  Breidert T.et.al.   9776363
[7] “Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.”  Urakami Y.et.al.   9808712
[8] “Localization of organic cation transporters OCT1 and OCT2 in rat kidney.”  Karbach U.et.al.   10997918
[9] “Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.”  Arndt P.et.al.   11502595
[10] “Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels.”  Slitt A.L.et.al.   11792693
[11] “Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.”  Denk G.U.et.al.   15122767
[12] “Purification and functional reconstitution of the rat organic cation transporter OCT1.”  Keller T.et.al.   16142924
[13] “Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.”  Ishiguro N.et.al.   15640376
[14] “Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.”  Kimura N.et.al.   16272756
[15] “Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation.”  Ciarimboli G.et.al.   15829703
[16] “Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.”  Amphoux A.et.al.   16581093
[17] “Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.”  Sturm A.et.al.   17567940
[18] “Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.”  Maeda T.et.al.   17553914

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPTVDDVLEQ VGEFGWFQKQ AFLLLCLISA SLAPIYVGIV FLGFTPGHYC QNPGVAELSQ 
61:	RCGWSQAEEL NYTVPGLGPS DEASFLSQCM RYEVDWNQST LDCVDPLSSL VANRSQLPLG 
121:	PCEHGWVYDT PGSSIVTEFN LVCGDAWKVD LFQSCVNLGF FLGSLVVGYI ADRFGRKLCL 
181:	LVTTLVTSVS GVLTAVAPDY TSMLLFRLLQ GMVSKGSWVS GYTLITEFVG SGYRRTTAIL 
241:	YQMAFTVGLV GLAGVAYAIP DWRWLQLAVS LPTFLFLLYY WFVPESPRWL LSQKRTTRAV 
301:	RIMEQIAQKN GKVPPADLKM LCLEEDASEK RSPSFADLFR TPNLRKHTVI LMYLWFSCAV 
361:	LYQGLIMHVG ATGANLYLDF FYSSLVEFPA AFIILVTIDR IGRIYPIAAS NLVTGAACLL 
421:	MIFIPHELHW LNVTLACLGR MGATIVLQMV CLVNAELYPT FIRNLGMMVC SALCDLGGIF 
481:	TPFMVFRLME VWQALPLILF GVLGLTAGAM TLLLPETKGV ALPETIEEAE NLGRRKSKAK 
541:	ENTIYLQVQT GKSSST