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Accession Number: | Q9NSA0 |
Protein Name: | OAT4 aka HOAT4 |
Length: | 550 |
Molecular Weight: | 59972.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), dehydroepiandrosterone sulfate, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, glutamate(2-), ochratoxin A, bile acid, osmolyte, estrone 3-sulfate |
Cross database links:
RefSeq: | NP_060954.1 |
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Entrez Gene ID: | 55867 |
Pfam: | PF00083 |
OMIM: |
607097 gene |
KEGG: | hsa:55867 hsa:55867 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0009897
C:external side of plasma membrane
GO:0005887
C:integral to plasma membrane
GO:0005452
F:inorganic anion exchanger activity
GO:0005515
F:protein binding
GO:0015347
F:sodium-independent organic anion transmembr...
GO:0015711
P:organic anion transport
GO:0015347
F:sodium-independent organic anion transmembrane transporter activity
GO:0046415
P:urate metabolic process
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References (14)[1] “Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.” Cha S.H.et.al. 10660625 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).” Zhou F.et.al. 15291761 [6] “The role of glycine residues in the function of human organic anion transporter 4.” Zhou F.et.al. 15102942 [7] “The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.” Zhou F.et.al. 15576633 [8] “Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.” Cha S.H.et.al. 10660625 [9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [10] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW THMLDNGSAV 61: STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA TATSWSEADT EPCVDGWVYD 121: RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM SGILVGSFIW GLLSYRFGRK PMLSWCCLQL 181: AVAGTSTIFA PTFVIYCGLR FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA 241: GQAALGGLAF ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA 301: RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML VVNFSLLISY 361: YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG RRTIQAGSQA MAGLAILANM 421: LVPQDLQTLR VVFAVLGKGC FGISLTCLTI YKAELFPTPV RMTADGILHT VGRLGAMMGP 481: LILMSRQALP LLPPLLYGVI SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ 541: EAVTVESTSL