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2.A.1.19.10
The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta (Lofthouse et al. 2015).  Functions in renal urate reabsorption (Prestin et al. 2014). Chlorine decreases the expression of the gene encoding this transporter (Suman et al. 2023).

Accession Number:Q9NSA0
Protein Name:OAT4 aka HOAT4
Length:550
Molecular Weight:59972.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), dehydroepiandrosterone sulfate, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, glutamate(2-), ochratoxin A, bile acid, osmolyte, estrone 3-sulfate

Cross database links:

RefSeq: NP_060954.1   
Entrez Gene ID: 55867   
Pfam: PF00083   
OMIM: 607097  gene
KEGG: hsa:55867    hsa:55867   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0009897 C:external side of plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005452 F:inorganic anion exchanger activity
GO:0005515 F:protein binding
GO:0015347 F:sodium-independent organic anion transmembr...
GO:0015711 P:organic anion transport
GO:0015347 F:sodium-independent organic anion transmembrane transporter activity
GO:0046415 P:urate metabolic process

References (14)

[1] “Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.”  Cha S.H.et.al.   10660625
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).”  Zhou F.et.al.   15291761
[6] “The role of glycine residues in the function of human organic anion transporter 4.”  Zhou F.et.al.   15102942
[7] “The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.”  Zhou F.et.al.   15576633
[8] “Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.”  Cha S.H.et.al.   10660625
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).”  Zhou F.et.al.   15291761
[13] “The role of glycine residues in the function of human organic anion transporter 4.”  Zhou F.et.al.   15102942
[14] “The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.”  Zhou F.et.al.   15576633

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW THMLDNGSAV 
61:	STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA TATSWSEADT EPCVDGWVYD 
121:	RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM SGILVGSFIW GLLSYRFGRK PMLSWCCLQL 
181:	AVAGTSTIFA PTFVIYCGLR FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA 
241:	GQAALGGLAF ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA 
301:	RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML VVNFSLLISY 
361:	YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG RRTIQAGSQA MAGLAILANM 
421:	LVPQDLQTLR VVFAVLGKGC FGISLTCLTI YKAELFPTPV RMTADGILHT VGRLGAMMGP 
481:	LILMSRQALP LLPPLLYGVI SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ 
541:	EAVTVESTSL