| |
|---|---|
| Accession Number: | O75751 |
| Protein Name: | Solute carrier family 22 member 3 |
| Length: | 556 |
| Molecular Weight: | 61280.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | monoamine molecular messenger |
Cross database links:
| Entrez Gene ID: | 6581 |
|---|---|
| Pfam: | PF07690 |
| KEGG: | hsa:6581 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0005329
F:dopamine transmembrane transporter activity
GO:0015651
F:quaternary ammonium group transmembrane transporter activity
GO:0019534
F:toxin transporter activity
GO:0051615
P:histamine uptake
GO:0032098
P:regulation of appetite
| |
References (3)[1] “Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.” Gruendemann D.et.al. 10196521 [2] “Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.” Verhaagh S.et.al. 9933568 [3] “Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.” Wu X.et.al. 10966924
| |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA 61: ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR 121: SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG 181: RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR 241: IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK 301: GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT 361: SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA 421: CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG 481: GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS 541: CKCGRNKKTP VSRSHL