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2.A.1.19.25
Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports cyclic nucleotodes and the anti-viral drug, acyclovir (Dahlin et al. 2013). Expressed mostly in liver, but also in kidney, brain and red blood cells (Sager et al. 2018). slc22 transporter homologs in flies, worms, and humans clarify the phylogeny of organic anion (OATs) and cation (OCTs) transporters (Eraly et al. 2004).

Accession Number:Q9Y694
Protein Name:Solute carrier family 22 member 7
Length:548
Molecular Weight:60026.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Acyclovir

Cross database links:

Genevestigator: Q9Y694
eggNOG: COG0477
HEGENOM: HOG000234569
Entrez Gene ID: 10864   
Pfam: PF07690   
KEGG: hsa:10864   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015347 F:sodium-independent organic anion transmembrane transporter activity
GO:0035634 P:response to stilbenoid

References (9)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Isolation of a family of organic anion transporters from human liver and kidney.”  Sun W.et.al.   11327718
[5] “Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.”  Enomoto A.et.al.   12023506
[6] “Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.”  Kimura H.et.al.   11907186
[7] “Human organic anion transporters mediate the transport of tetracycline.”  Babu E.et.al.   11855680
[8] “Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).”  Kobayashi Y.et.al.   15901346
[9] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA LPGAPANFSH 
61:	QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS RGELEDEPAT VPCSQGWEYD 
121:	HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV 
181:	STLVLGLASA ASVSYVMFAI TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW 
241:	TGGVMLLALV GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH 
301:	CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC VVVWFGVNFS 
361:	YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA GRRLTQAGTL LGTALAFGTR 
421:	LLVSSDMKSW STVLAVMGKA FSEAAFTTAY LFTSELYPTV LRQTGMGLTA LVGRLGGSLA 
481:	PLAALLDGVW LSLPKLTYGG IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE 
541:	MPMKQVQN