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2.A.1.19.28
Solute carrier family 22 member 23.  The rat orthologue may be inactive (Bennett et al. 2011). Human SLC22A23 is expressed in many tissues including brain (brain organic cation transporter (BOCT2) (Bennett et al. 2011).

Accession Number:A1A5C7
Protein Name:Solute carrier family 22 member 23
Length:686
Molecular Weight:73748.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown, NONE

Cross database links:

Genevestigator: A1A5C7
eggNOG: NOG275019
HEGENOM: HOG000124569
Entrez Gene ID: 63027   
Pfam: PF00083   
KEGG: hsa:63027   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022857 F:transmembrane transporter activity
GO:0006811 P:ion transport

References (4)

[1] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.”  Jacobsson J.A.et.al.   17714910

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI QPLPPLHPGG 
61:	GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV LLTWIPALFI GFSQFSDSFL 
121:	LDQPNFWCRG AGKGTELAGV TTTGRGGDMG NWTSLPTTPF ATAPWEAAGN RSNSSGADGG 
181:	DTPPLPSPPD KGDNASNCDC RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL 
241:	IFGYLITGCI ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT 
301:	LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII CPFLLMLLYW 
361:	SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG VIPELEKELS RRPKKVCIVK 
421:	VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR SMMGHEVKVP LLENFYADYY TTASIALVSC 
481:	LAMCVVVRFL GRRGGLLLFM ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF 
541:	SIVGMFASHA VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH 
601:	HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP LLLTNAELKD 
661:	YSGLHDAAAA GDTLPEGATA NGMKAM