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2.A.1.19.32
Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1). This system is required for hepatocellular carcinoma proliferation and metastasis (Fang et al. 2021). SLC22A15 prefers zwitterionic compounds over cations and anions. Eight zwitterions transported include ergothioneine, carnitine, carnosine, gabapentin, as well as four cations including MPP+ , thiamine and cimetidine. Carnosine was a specific substrate of SLC22A15 among the transporters in the SLC22A family. SLC22A15 transport was sodium-dependent and exhibited higher Km values for ergothioneine, carnitine, and carnosine compared to previously identified transporters for these ligands (Yee et al. 2020Yee et al. 2020).

Accession Number:Q8IZD6
Protein Name:Solute carrier family 22 member 15
Length:547
Molecular Weight:60540.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown, NONE

Cross database links:

Entrez Gene ID: 55356   
Pfam: PF00083   
KEGG: hsa:55356   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022857 F:transmembrane transporter activity
GO:0006811 P:ion transport

References (6)

[1] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.”  Eraly S.A.et.al.   12372408
[2] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[6] “Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines.”  Molderings G.J.et.al.   15028572

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW DLAELLPNQS 
61:	HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE WFLIANRSYK VSAASSFFFS 
121:	GVFVGVISFG QLSDRFGRKK VYLTGFALDI LFAIANGFSP SYEFFAVTRF LVGMMNGGMS 
181:	LVAFVLLNEC VGTAYWALAG SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL 
241:	LSLFIPESPR WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR 
301:	YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS YPLCIYLINQ 
361:	KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS HSLSLLGKLT ISAAFNIVYI 
421:	YTSELYPTVI RNVGLGTCSM FSRVGGIIAP FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL 
481:	LPETLNSPLL ETFSDLQVYS YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD 
541:	EETQMIK