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| Accession Number: | Q9R1U7 |
| Protein Name: | Oat3 |
| Length: | 536 |
| Molecular Weight: | 59186.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Basolateral cell membrane1 / Multi-pass membrane protein2 |
| Substrate | dicarboxylic acid dianion, p-aminohippuric acid, ochratoxin A, cimetidine, estrone 3-sulfate |
Cross database links:
| RefSeq: | NP_112622.1 |
|---|---|
| Entrez Gene ID: | 83500 |
| Pfam: | PF00083 |
| KEGG: | rno:83500 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0016021
C:integral to membrane
GO:0015651
F:quaternary ammonium group transmembrane tra...
GO:0015697
P:quaternary ammonium group transport
GO:0031427
P:response to methotrexate
GO:0009636
P:response to toxin
GO:0055085
P:transmembrane transport
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References (11)[1] “Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.” Kusuhara H.et.al. 10224140 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.” Nagata Y.et.al. 11961115 [4] “Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.” Hasegawa M.et.al. 11861777 [5] “Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.” Hasegawa M.et.al. 12660303 [6] “Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier.” Kikuchi R.et.al. 12684544 [7] “Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient.” Sweet D.H.et.al. 12488248 [8] “Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier.” Kikuchi R.et.al. 15292460 [9] “Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.” Nagata Y.et.al. 15319347 [10] “Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus.” Nagata Y.et.al. 15389674 [11] “Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.” Deguchi T.et.al. 15846470
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTFSEILDRV GSMGPFQYLH VTLLALPVLG IANHNLLQIF TATTPVHHCR PPPNASIGPW 61: VLPLDPNGKP EKCLRFVHLP NASLPNDTQR ATEPCLDGWI YNSTRDTIVI EWDLVCSSNK 121: LKEMAQSIFM AGILVGGPVI GELSDRFGRK PILTWSYLML AASGSGAAFS PSLPVYMIFR 181: FLCGCSISGI SLSTVILNVE WVPTSMRAIS STSIGYCYTI GQFILSGLAY AIPQWRWLQL 241: TSSAPFFIFS LLSWWVPESI RWLVLSGKYS KALKTLQRVA TFNGKKEEGK KLTIEELKFN 301: LQKDITSAKV KYGLSDLFRV SILRRVTFCL SLAWFSTGFA YYSLAMGVEE FGVNIYILQI 361: IFGGVDIPAK FITILSLSYL GRRITQSFLL LLAGGAILAL IFVPSEMQLL RTALAVFGKG 421: CLSGSFSCLF LYTSELYPTV LRQTGMGISN VWARVGSMIA PLVKITGELQ PFIPNVIFGT 481: TALLGGSAAF FLLETLNRPL PETIEDIQNW HKQVQKTKQE SEAEKASQII PLKTGG