2.A.1.2.111
Zinc-induced facilitator-like protein 1, ZIFL1 or Tpo1p  of 478 aas and 12 TMSs. It confers resistance to the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D) and is transcriptionally activated in response to this herbicide. Tpo1p is required to reduce the intracellular concentration of 2,4-D (Cabrito et al. 2009). K⁺ may be its physiological substrate, and it may play a dual role in polar auxin transport and drought stress tolerance (Remy et al. 2013). It is also involved in auxin efflux and acts as a positive regulator of shootward transport at the root apex. Possibly, it may mediate proton efflux from the vacuolar compartment (Remy et al. 2013).