2.A.1.2.128
MDR1 of Candida auris of 549 aas and 12 TMSs in a 6 + 6 TMS arrangement. It is 61% idential to TC# 2.A.1.2.6 and is inhibited by isavuconozole. Alterations in membrane lipid composition and modulation of this drug efflux
transporter are critical processes contributing to isavuconozole (and other drug) susceptibilities (Balla et al. 2024).
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| Accession Number: | WZC14603.1 |
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| Protein Name: | WZC14603.1 Multidrug resistance protein 1 [Candidozyma auris] |
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| Length: | 550 |
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| Molecular Weight: | |
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| Species: | Candidozyma auris [498019] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
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1: MFLYKFVRES FFGRSLYHLS GRKVFTYPEE SPDYVIPAKY LGKDEAGIES DVQEKAGASD
61: TPVDSDSSSQ STKTNHILVD WEGEDDPENP YNWPLKYKII FIAQIMILTA FVYMASAIYT
121: PGIEEIMKDM GVGQVVATLP LTLFVFGYGI GPMVFSPLSE NARFGRTSIY IITLFIFFIL
181: QIPTALVDNI AGLCILRFIA GFFASPCLAT GGASVGDVIN LPYIPVGISF WSIAAVCAPS
241: SGPLFGAILS VKADYHWTFW FVCITSGASF VVLGWMLPES YSKTILYRKA ERLRALTGNQ
301: DIVSEGHLEN AKFSTHEMLV ETLWRPFEVI IFEPVVLLIN IYIGLVYSVM YLWFEAFPIV
361: FVQVKGFTLI EMGVAYMCIL VGILIAAAFY IPTIYHQFTK KMLSNQEVVP EVFIPMAIVG
421: SIIMPIGVFI FGWTAAEDLH WIGPLIGAAV FAAGAFLVFQ TLFNYLSMSF WRYLASVFAG
481: NDLFRSMMAG AFPLFGKPLF LNLRTNRFAV GWGSSLLGFI CVGMIAIPVL FYLNGPKLRA
541: RSKYAGAGA