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2.A.1.2.28
The vesicular acetylcholine transporter, VAChT (pumps acetylcholine into synaptic vesicles).  The acetyl choline and vesamicol binding sites have been identified (Ojeda et al. 2004) and are near the luminal end of the transport pathway (Khare et al. 2010). The SLC18 family has been reviewed (Lawal and Krantz 2018). VAChT in the brain is an important presynaptic cholinergic biomarker (Hu et al. 2023).

Accession Number:Q16572
Protein Name:VAChT
Length:532
Molecular Weight:56961.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate acetylcholine, acetylcholine

Cross database links:

RefSeq: NP_003046.2   
Entrez Gene ID: 6572   
Pfam: PF07690   
OMIM: 600336  gene
KEGG: hsa:6572    hsa:6572   

Gene Ontology

GO:0060201 C:clathrin sculpted acetylcholine transport v...
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005277 F:acetylcholine transmembrane transporter act...
GO:0015870 P:acetylcholine transport
GO:0055085 P:transmembrane transport
GO:0030121 C:AP-1 adaptor complex
GO:0030122 C:AP-2 adaptor complex
GO:0043679 C:axon terminus
GO:0060201 C:clathrin sculpted acetylcholine transport vesicle membrane
GO:0008021 C:synaptic vesicle
GO:0042166 F:acetylcholine binding
GO:0005277 F:acetylcholine transmembrane transporter activity
GO:0007269 P:neurotransmitter secretion

References (7)

[1] “Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus.”  Erickson J.D.et.al.   8071310
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus.”  Erickson J.D.et.al.   8071310
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MESAEPAGQA RAAATKLSEA VGAALQEPRR QRRLVLVIVC VALLLDNMLY MVIVPIVPDY 
61:	IAHMRGGGEG PTRTPEVWEP TLPLPTPANA SAYTANTSAS PTAAWPAGSA LRPRYPTESE 
121:	DVKIGVLFAS KAILQLLVNP LSGPFIDRMS YDVPLLIGLG VMFASTVLFA FAEDYATLFA 
181:	ARSLQGLGSA FADTSGIAMI ADKYPEEPER SRALGVALAF ISFGSLVAPP FGGILYEFAG 
241:	KRVPFLVLAA VSLFDALLLL AVAKPFSAAA RARANLPVGT PIHRLMLDPY IAVVAGALTT 
301:	CNIPLAFLEP TIATWMKHTM AASEWEMGMA WLPAFVPHVL GVYLTVRLAA RYPHLQWLYG 
361:	ALGLAVIGAS SCIVPACRSF APLVVSLCGL CFGIALVDTA LLPTLAFLVD VRHVSVYGSV 
421:	YAIADISYSV AYALGPIVAG HIVHSLGFEQ LSLGMGLANL LYAPVLLLLR NVGLLTRSRS 
481:	ERDVLLDEPP QGLYDAVRLR ERPVSGQDGE PRSPPGPFDE CEDDYNYYYT RS