Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.2.34
The MDR efflux pump, PmrA (exports fluoroquinolone and other compounds) and other components including the antimicrobial peptide, colistin (Martinez-Garriga et al. 2007; Pamp et al., 2008).  o-Cymen-5-ol nanoemulsion reverses colistin resistance in multidrug-resistant Klebsiella pneumoniae infections, and probably in other bacteria (Sheng et al. 2024).

Accession Number:P0A4K4
Protein Name:Multi-drug resistance efflux pump pmrA
Length:399
Molecular Weight:42840.00
Species:Streptococcus pneumoniae [1313]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate colistin, fluoroquinolone antibiotic

Cross database links:

RefSeq: NP_345453.1   
Entrez Gene ID: 931481   
Pfam: PF07690    PF00083   
KEGG: spn:SP_0972   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.”  Gill M.J.et.al.   9869592
[2] “Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.”  Tettelin H.et.al.   11463916

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MTEINWKDNL RIAWFGNFLT GASISLVVPF MPIFVENLGV GSQQVAFYAG LAISVSAISA 
61:	ALFSPIWGIL ADKYGRKPMM IRAGLAMTIT MGGLAFVPNI YWLIFLRLLN GVFAGFVPNA 
121:	TALIASQVPK EKSGSALGTL STGVVAGTLT GPFIGGFIAE LFGIRTVFLL VGSFLFLAAI 
181:	LTICFIKEDF QPVAKEKAIP TKELFTSVKY PYLLLNLFLT SFVIQFSAQS IGPILALYVR 
241:	DLGQTENLLF VSGLIVSSMG FSSMMSAGVM GKLGDKVGNH RLLVVAQFYS VIIYLLCANA 
301:	SSPLQLGLYR FLFGLGTGAL IPGVNALLSK MTPKAGISRV FAFNQVFFYL GGVVGPMAGS 
361:	AVAGQFGYHA VFYATSLCVA FSCLFNLIQF RTLLKVKEI