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2.A.1.2.53
MDR pump, SLC22A18 in lung cancer cells (Lei et al., 2012). It has 424 aas and 12 TMSs. Allelic loss in the absence of mutations in the polyspecific transporter gene BWR1A on 11p15.5 in hepatoblastoma has been shown (Albrecht et al. 2004).

Accession Number:Q96BI1
Protein Name:Solute carrier family 22 member 18
Length:424
Molecular Weight:44846.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

Entrez Gene ID: 5002   
Pfam: PF07690   
KEGG: hsa:5002    hsa:5002   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0044444 C:cytoplasmic part
GO:0016021 C:integral to membrane
GO:0005635 C:nuclear envelope
GO:0015238 F:drug transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0031625 F:ubiquitin protein ligase binding
GO:0007588 P:excretion
GO:0015695 P:organic cation transport

References (16)

[1] “Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.”  Lee M.P.et.al.   9751628
[2] “A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.”  Morisaki H.et.al.   9802569
[3] “Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.”  Cooper P.R.et.al.   9570947
[4] “IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.”  Dao D.et.al.   9499412
[5] “Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.”  Schwienbacher C.et.al.   9520460
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules.”  Reece M.et.al.   9744804
[8] “Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.”  Yamada H.Y.et.al.   16314844
[9] “Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.”  Lee M.P.et.al.   9751628
[10] “A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.”  Morisaki H.et.al.   9802569
[11] “Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.”  Cooper P.R.et.al.   9570947
[12] “IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.”  Dao D.et.al.   9499412
[13] “Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.”  Schwienbacher C.et.al.   9520460
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules.”  Reece M.et.al.   9744804
[16] “Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.”  Yamada H.Y.et.al.   16314844

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL SRKLGLDSIA 
61:	FGYLQTTFGV LQLLGGPVFG RFADQRGARA ALTLSFLAAL ALYLLLAAAS SPALPGVYLL 
121:	FASRLPGALM HTLPAAQMVI TDLSAPEERP AALGRLGLCF GVGVILGSLL GGTLVSAYGI 
181:	QCPAILAALA TLLGAVLSFT CIPASTKGAK TDAQAPLPGG PRASVFDLKA IASLLRLPDV 
241:	PRIFLVKVAS NCPTGLFMVM FSIISMDFFQ LEAAQAGYLM SFFGLLQMVT QGLVIGQLSS 
301:	HFSEEVLLRA SVLVFIVVGL AMAWMSSVFH FCLLVPGLVF SLCTLNVVTD SMLIKAVSTS 
361:	DTGTMLGLCA SVQPLLRTLG PTVGGLLYRS FGVPVFGHVQ VAINTLVLLV LWRKPMPQRK 
421:	DKVR