2.A.1.21.22
Macrolide efflux pump, MefE (Mef; MefA) of 405 aas. Induced by erythromycin and the antimicrobial peptide, LL-37 (Zähner et al. 2010). May act in conjunction with Mel (Q93QE4), an ABC-type ATPase that is encoded in the same operon with the mefA gene (Ambrose et al. 2005).
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| Accession Number: | Q7BKK4 |
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| Protein Name: | Macrolide efflux protein E |
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| Length: | 405 |
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| Molecular Weight: | 43925.00 |
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| Species: | Streptococcus pneumoniae [1313] |
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| Number of TMSs: | 12 |
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| Substrate |
macrolide, erythromycin A |
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1: MEKYNNWKRK FYAIWAGQAV SLITSAILQM AIIFYLTEKT GSAMVLSMAS LVGFLPYAIL
61: GPAIGVLVDR HDRKKIMIGA DLIIAAAGAV LAIVAFCMEL PVWMIMIVLF IRSIGTAFHT
121: PALNAVTPLL VPEEQLTKCA GYSQSLQSIS YIVSPAVAAL LYSVWDLNAI IAIDVLGAVI
181: ASITVAIVRI PKLGNQVQSL EPNFIREMKE GVVVLRQNKG LFALLLLGTL YTFVYMPINA
241: LFPLISMEHF NGTPVHISIT EISFAFGMLA GGLLLGRLGG FEKHVLLITS SFFIMGTSLA
301: VSGILPPNGF VIFVVCCAIM GLSVPFYSGV QTALFQEKIK PEYLGRVFSL IGSIMSLAMP
361: IGLILSGFFA DKIGVNHWFL LSGILIIGIA IVCQMITEVR KLDLK